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  5. Effects of novel triazole-dithiocarbamate based LSD1 selective inhibitors on gastric cancer cell gro

Effects of novel triazole-dithiocarbamate based LSD1 selective inhibitors on gastric cancer cell gro

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：drifter
【摘 要】
：
The post-translational modifications of histone, eg methylation and demythalation,regulate chromatin structure as well as gene activation and repression.Lysinespecific demythelase 1 (LSD1), the first
【作 者】
：
Yi-chao ZHENG Wen-lei LV Jin-lian MA Ang YANG Jin-feng LI Zhi-ru WANG Wen ZHAO Hong-min LIU 
【机 构】
：
New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
LSD1 inhibitor epigenetics gastric cancer 
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论文部分内容阅读
The post-translational modifications of histone, eg methylation and demythalation,regulate chromatin structure as well as gene activation and repression.Lysinespecific demythelase 1 (LSD1), the first identified histone demythalase since 2004, has been reported to be up-regulated in numbers of cancers, including gastric cancer.
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