IRF3相关论文
细胞衰老（Cellular Senescence）是一种细胞状态,其特征为不可逆的细胞周期停滞和特定的衰老相关分泌表型,是癌症等多种年龄相关疾病......
＜正＞目的:研究小G蛋白Rab7b在TLR4信号转导过程中的作用及其机制。方法:以小鼠巨噬细胞系RAW264．7为模型,将表达Rab7b的质粒转染细胞......
目的:通过雨蛙素诱导急性胰腺炎大鼠及细胞模型,探讨Wip1介导急性胰腺炎演进的分子机制。研究方法:取8周龄SD大鼠20只,随机平均分......
目的:NLRP3炎症小体是先天免疫系统的重要组成部分,它通过介导caspase-1激活和促炎细胞因子IL-1β/IL-18的分泌,以响应微生物感染......
甲型流感病毒属于正粘病毒科,是一种分节段的单股负链RNA病毒。甲型流感病毒以呼吸道上皮细胞为目标,利用宿主细胞进行复制和传播,......
宿主细胞通过模式识别受体识别入侵细胞的病原微生物,再通过级联放大机制诱导干扰素产生。cGAS是最主要的胞质DNA识别受体,在识别......
第一部分早期ARDS调控巨噬细胞M1极化关键分子的筛选目的:目前已知参与巨噬细胞M1极化的分子诸多,但缺乏在ARDS早期发挥作用的证据......
先天免疫应答作为人体的第一道防线,在机体发挥抗病毒功能中起着重要作用。当病毒感染细胞时,可被宿主细胞内不同的模式识别受体识......
Identification of grouper interferon regulatory factor 3 involved in antiviral immune response again
Interferon regulatory factor 3(IRF3)is an important transcription factor which regulates the expression of interferon(IF......
干扰素是一类具有多种生物学功能的细胞因子。哺乳动物中，通过分析干扰素家族成员在氨基酸序列、基因座排列、受体系统和信号通路等......
IRF3 and IRF7 up-regulate the transcription levels of PKR and PKZ in grass carp(Ctenopharyngodon ide
PKR(double-stranded RNA-dependent protein kinase)and PKZ(protein kinase containing Z-DNA binding domain)are two importan......
Glycyrrhizin inhibits the inflammatory response in mouse mammary epithelial cells and mouse mastitis
Glycyrrhizin, a triterpene glycoside isolated from licorice root, has been known to exhibit anti-inflammatory activities......
The aim of this study was to investigate the effect of glycyrrhizin on LPS-induced endotoxemia in mice and clarify the p......
Cyanidin-3-O-β-glucoside inhibits lipopolysaccharide-induced inflammatory response in mouse mastitis
Cyanidin-3-O-β-glucoside (CAS No.7084-24-4), a typical anthocyanin pigment that exists in the human diet,has been repor......
Protein phosphatase PP1 negatively regulates the Toll-like receptor-and RIG-Ⅰ-like receptor-triggere
The production of type Ⅰ interferon must be tightly regulated, and the aberrant production of this protein is harmful o......
Interferon regulatory factor 3 (IRF3) plays an essential role in virus-induced type Ⅰ interferon (IFN) production and h......
TRIM26 negatively regulates interferon-β production through polyubiquitination and degradation of nu
Virus infection leads to the activation of transcription factor IRF3 and subsequent production of type Ⅰ inteferons, wh......
Pseudomonas aeruginosa (P.aeruginosa) is the major pathogen in the morbidity and mortality of ventilator associated pneu......
PTEN is one of the most frequently mutated tumor suppressors in human cancer.While its function in tumor suppression is ......
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA Binding Activity of Interferon
Accurate cellular localization plays a crucial role in the effective function of most signaling proteins and nuclear tra......
PTEN is one of the most frequently mutated tumor suppressors in human cancer.While its function in tumor suppression is ......
Object:To observe the effect of QiWei BaiZhu Powder on expression of IRF3、 IRF7 and IFN in suckling mice infected by HR......
CaMKⅡ promotes TLR-triggered proinflammatory cytokine and type Ⅰ interferon production by directly b
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会议
干扰素调节因子是转录调控因子家族中的成员，它们参与了I 型干扰素和干扰素刺激基因的转录调控过程，并且还能反馈调节自身的表达......
目的:探讨urotensinⅡ(UⅡ)受体拮抗剂urantide对急性肝衰竭小鼠肝组织干扰素调节因子3(interferon regulatory factor 3,IRF3)表......
1 CXCL-10概述rnCXCI,10(又名IP10,即IFN-γ-inducible protein10)是在1985年由Luster等首先报道的,是用分子生物学技术从活化U937......
目的:系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种复杂的自身免疫性疾病。目前全基因组关联研究(genome-wide associ......
目的研究miR-628-5p在EV71诱导的固有免疫反应中的作用,为阐明EV71与宿主的交互作用提供理论依据。方法1.收集EV71(MOI=1,24 h)感......
学位
长链非编码RNA(lncRNA)是一类长度大于或等于200bp且不编码蛋白质的RNA,早先的研究中被认为是基因表达中的“噪音”,但随着人类基......
目的:验证长链非编码RNA(long noncoding RNA,lncRNA)MALAT1与干扰素调节因子3(Interferon regulation factor 3,IRF3)和干扰素调......
轮状病毒作为呼肠孤病毒属的双链RNA病毒,是世界范围内引起婴幼儿急性肠胃炎的主要病原体。轮状病毒主要感染小肠上皮细胞。已有证......
天然免疫在人和动物机体稳态中发挥重要作用。近年来维生素,植物提取物,营养素如氨基酸等在调节免疫方面的研究越来越引起重视。谷......
口蹄疫（foot-and-mouth disease,FMD）由口蹄疫病毒（foot-and-mouth disease virus,FMDV）引起的一种烈性、急性和高度传染性疾病,主要感......
目的:1. 检测小鼠肝缺血再灌注（ischemia/reperfusion,I/R）损伤体外模型中Micro RNA-148a（miR-148a）、钙离子/钙调蛋白依赖蛋白激酶Ⅱ......
TANK-binding kinase 1 (TBK1),a core kinase of antiviral pathways,activates the production of interferons (IFNs).It has b......
目的重组并包装干扰素调节因子3(interferon regulator factor 3,IRF3)短发夹RNA(short hairpin RNA,sh RNA)腺病毒,研究该病毒对R......
肠道病毒71型(EV71)感染引起手足口病并可导致神经源性疾病,而免疫受损或不成熟与EV71感染的发病率和致死率升高密切相关。Ⅰ型干......
为了研究EWS蛋白质对IRF3转录活性的影响,以及EWS蛋白对IRF3信号通路的调节,在真核细胞293T中表达Flag-EWS蛋白质,通过双荧光报告......
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The innate immune response is the first line of host defense to eliminate viral infection.Patte recognition receptors in......
为了研究14-3-3蛋白是否参与了IRF3信号通路,以及14-3-3蛋白质对IRF3转录活性的影响,在真核细胞293T中表达14-3-3蛋白质的三种亚型......
