MPTP相关论文
为了研究梓醇（Catalpol）对甲基-4-苯基1,2,3,6-四氢吡啶(1-methyl-4-phenyl-1,2,3,6-tetmhydropyridine, MPTP)所诱导的亚急性帕金森......
帕金森病（Parkinson disease,PD）是中老年人常见的一种神经退行性疾病,平均发病年龄60岁左右,且PD的增长速度在神经系统疾病中位居第......
帕金森病(PD)研究使用最广泛的动物模型是神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的小鼠损伤模型.该模型大致可以分为3......
目的 探讨AMG9810对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的SD大鼠帕金森病(PD)模型学习记忆能力的影响及其机制.方法 采用MP......
背景:1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,MPTP)诱导的帕金森病小鼠模型是较为广泛使......
Acute Restraint Stress Augments 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurotoxicity via Incre
As an environmental risk factor,psychological stress may trigger the onset or accelerate the progression of Parkinson\......
MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcome
In this study,we developed a systemic PD model in middle-aged cynomolgus monkeys using individualized low-dose MPTP,to e......
探究不同分子形式鱼油对MPTP 诱导的小鼠脑内氧化应激损伤的效果及其机制。本研究将C57/BL 小鼠按体重随机分对照组、MPTP 处理组(......
Parkinsons disease (PD) is an age-related neurodegenerative disease.Although its pathogenic mechanism is not understand,......
为了探讨ATP、Bax 对E.tenella 宿主细胞凋亡的调控作用,采用原代鸡胚盲肠上皮细胞培养技术和流式细胞技术等,对ATP 和Bax 抑制剂......
目的：进一步研究优选缺血后调适方案对大鼠骨骼肌缺血再灌注损伤的保护作用及初步探究RISK通路机制。方法：将18只健康成年雄性SD大鼠......
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The L-type calcium channel antagonist isradipine reduce iron accumulation in the substia nigra in MP
Parkinsons disease(PD)is pathologically characterized by the progressive loss of dopaminergic neurons in the substantia ......
Oxidative stress is actively involved in dopaminergic neuronal degeneration in Parkinsons disease (PD).Our previous stud......
MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)可以使灵长类动物产生帕金森病样症状和病理改变,且这些症状可以被左旋多巴......
Introduction: Parkinsons disease(PD)is a chronic neurodegenerative disease of the central nervous system.The main pathol......
Parkin ameliorates dopaminergic neurodegeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyr
Mutations in the parkin gene are currently thought to be the most common cause of familial Parkinsonism.Overexpression o......
本研究以C57BL小鼠为研究对象,用MPTP制备帕金森病鼠模型,观察人参皂苷RgI预处理对MPTP诱导的黑质神经元凋亡的保护作用,并探讨此......
Upregulation of long noncoding RNA MEG3 Induced by Heat Stress Contributes to Apoptosis of Rat Cardi
Mitochondria play a key role in cardiomyocytes apoptosis induced by heat stress.Our previous study indicate that TR3 bin......
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[背景]帕金森病(Parkinson disease,PD)是一种成年发病的神经退行性疾病,以a-突触核蛋白异常聚集和黑质致密部多巴胺能神经元的逐......
Neuroprotective effects of piperine on the1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parki
Parkinsons disease (PD) is second only to Alzheimers disease as the most common and debilitating age-associated neurodeg......
The compound Chinese medicine “Kang Fu Ling” protects against high power microwave-induced myocardia
Background: The prevention and treatment of Microwave-caused cardiovascular injury remains elusive.This study investigat......
目的：观察盐生肉苁蓉苯乙醇总苷在MPTP诱导的C57小鼠的帕金森病模型中的神经保护作用。方法：通过滚筒和自主活动实验研究动物的整体......
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Rational Design of Two-photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Live
Monoamine oxidases(MAOs)are important mammalian enzymes that catalyze the transformation of various neurotransmitters in......
线粒体是细胞凋亡的调控中心.在线粒体途径细胞凋亡过程中,线粒体结构和功能发生重构,线粒体外膜通道形成,导致一系列凋亡蛋白如Cy......
帕金森病（Parkinson’s disease，PD）是一种神经退行性疾病，其特征性病变为黑质多巴胺能神经元选择性丧失，继而引发纹状体内多巴胺（Dopami......
目的探究不同病因引起的帕金森病(PD)与中枢神经系统炎症的关系。方法分别选用1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)慢性给药和A5......
探讨鼠尾草酸(carnosic acid,CA)对1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,MPTP)诱导的......
Melatonin attenuates MPTP-induced neurotoxicity via preventing Cdk5-mediated autophagy and α-synucle
Autophagy is involved in the pathogenesis of neurodegenerative diseases including Parkinsons disease(PD).However,lit......
Proteomic analysis of substantia nigra and striatal tissue in the MPTP mouse model of Parkinsons dis
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To investigate the neuroprotective effects of LK001 in a nonhuman primate model of Parkinsons disease induced by 1-Methy......
目的:通本研究采用PD 细胞和小鼠模型以及AD 转基因小鼠模型,应用行为学、形态学和分子生物学等手段,探讨姜黄素对神经元的保护作......
紫红獐牙菜提取物是一种应用广泛的中国传统中药,其抗乙型肝炎病毒,保肝,降低血糖等作用已经被报道。在本研究中,我们发现紫红獐牙......
目的：观察银杏叶提取物(ginkgo biloba extract,GBE)对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导不同年龄段的帕金森(PD)小鼠......
亲环素D(Cyclophilin D,CypD)是定位于线粒体膜上的亲免素家族成员,与腺嘌呤核苷酸转位蛋白(ANT)、电压依赖性阴离子通道(VDAC......
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目的探究丁酸钠(NaB)对帕金森病(PD)模型小鼠运动功能及焦虑行为的影响及作用。方法选用健康C57BL/6小鼠,按照随机数字,分为正常组......
力竭运动会引起心脏心肌组织的损伤,导致心肌能量代谢障碍等不良反应的发生,而线粒体作为心肌能量代谢中最重要的细胞器,也将产生......
目的研究胰高血糖素样肽-1类似物(Val8)GLP-1-Glu-PAL对MPTP诱导的帕金森病小鼠模型黑质区多巴胺能神经元的保护作用。方法取10～12......
The work is to explore the relationship between the levels of cytokines (IL-1β and IL-6) in C57BL/6J mice treated with ......
