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２６例急性心肌梗死患者，应用索他洛尔治疗，并测定心率变异功率谱，发现用药后５天、１０天之功率谱较用药前有明显增加（Ｐ＜０．０５），与对照组相比亦有显著差异（Ｐ＜０．０５），应用索他洛尔组心肌梗死后心律失常发生率较对照组明显降低。
Twenty-six patients with acute myocardial infarction were treated with sotalol, and the power spectrum of heart rate variability was determined. The power spectrum at 5 days and 10 days after treatment was significantly higher than that before treatment (P <0.05) (P <0.05). The incidence of arrhythmia after myocardial infarction in sotalol group was significantly lower than that in control group.