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纳米颗粒与生物膜之间的相互作用,对于纳米颗粒在细胞成像、生物传感器设计、药物输送及疾病诊断和治疗等方面的应用有着重要的影响。本文采用自洽场理论,考察了不同相互作用条件下,纳米颗粒跨膜输运过程中生物膜的形变情况,以及系统自由能的变化情况。结果表明,在纳米颗粒跨膜输运的过程中,随着纳米颗粒与生物膜之间相互作用的改变,生物膜的形状呈现出不同的形变;进一步,通过对系统自由能变化的分析,发现纳米颗粒与生物膜之间的相互作用能显著影响颗粒跨膜输运的难易程度。这些结果将为纳米颗粒在生物领域的相关应用提供一些理论参考。
The interaction between nanoparticles and biofilms plays an important role in the applications of nanoparticles in cell imaging, biosensor design, drug delivery and disease diagnosis and treatment. In this paper, the self-consistent field theory was used to investigate the biofilm deformation during transmembrane transport and the change of free energy of the system under different interaction conditions. The results showed that during the transmembrane transport of nanoparticles, the shape of the biofilm showed different deformations as the interaction between the nanoparticles and the biofilm changed. Furthermore, by analyzing the change of the free energy of the system, we found that The interaction between nanoparticles and biofilms can significantly affect the ease of transmembrane transport of the particles. These results will provide some theoretical references for the application of nanoparticles in the biological field.