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利用放射性核素标记乏氧显像剂 ,通过SPECT显像无创伤性探测组织缺血、缺氧状态 ,是目前放射性新药的一个研究方向。乏氧显像是以乏氧组织显像剂作为示踪剂探测机体内缺氧、缺血组织的显像过程[1 3 ] 。影响乏氧显像灵敏度的因素有放射性药物到达缺血区域的量、在乏氧组织中的
The use of radionuclide labeled hypoxic imaging agents, noninvasive detection of tissue ischemia and hypoxia by SPECT imaging is a current research direction of radioactive drugs. Hypoxic imaging is the use of hypoxic tissue imaging agent as a tracer to detect the development of hypoxic and ischemic tissues in vivo [13]. Factors that affect the sensitivity of hypoxic imaging are the amount of radiopharmaceutical that reaches the ischemic area, in hypoxic tissues