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目的研制新型心肌灌注显像剂９９ＴｃｍＮ，Ｎ′亚乙基二（乙酰丙酮亚胺）二［三（３甲氧基１丙基）膦］（简称Ｑ３）。方法合成显像剂的配体Ｎ，Ｎ′亚乙基—二（乙酰丙酮亚胺）和三（３甲氧基１丙基）膦后，用ＳｎＣｌ２·２Ｈ２Ｏ在强碱性条件下，还原９９ＴｃｍＯ－４标记Ｎ，Ｎ′亚乙基—二（乙酰丙酮亚胺），再加入三（３甲氧基１丙基）膦反应１０ｍｉｎ，制得９９ＴｃｍＱ３。进行９９ＴｃｍＱ３小鼠体内分布和家兔显像实验，以及体外稳定性和急性毒性实验。结果９９ＴｃｍＱ３的心肌摄取快，摄取率高，注射后５ｍｉｎ时每克心肌组织的摄取约为注射剂量的２４６６％，滞留时间长，注射后４ｈ心肌清除不明显；血液、肺、肝脏清除均快。该显像剂无毒副作用，稳定性达６ｈ以上。结论９９ＴｃｍＱ３是提高心肌灌注显像质量的较理想的显像剂。
Objective To develop a new myocardial perfusion imaging agent 99Tcm N, N ethylene two (acetylacetoneimine) bis [tris (3 methoxy 1 propyl) phosphine] (referred to as Q3). Methods After synthesizing the ligands of N, N’-ethylene-bis (acetylacetoneimine) and tris (3-methoxy-1-propyl) phosphine, Under 99TcmO-4 labeled N, N’-ethylene-bis (acetylacetoneimine), and then added three (3 methoxy 1 propyl) phosphine reaction 10min, obtained 99Tcm Q3. 99Tcm Q3 mice in vivo distribution and imaging experiments in rabbits, as well as in vitro stability and acute toxicity experiments. Results The myocardial uptake of 99TcmQ3 was fast and the rate of uptake was high. The myocardial tissue intake per gram at 5 min after injection was about 2466% of the injected dose, with a long residence time and no significant myocardial clearance at 4h after injection. Blood, lung and liver Clear all soon. The imaging agent has no toxic side effects and the stability is up to 6 hours. Conclusion 99Tcm Q3 is to improve the quality of myocardial perfusion imaging ideal imaging agent.