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死于帕金森氏病(PD)的患者,其脑内病理变化已为人所熟知,主要损及脑于的色素核团,尤其黑质致密带。但不含儿茶酚胺的非色素区域,如未名带等,亦可受损。PD 病理改变的特征是出现ewy 氏体。生化方面的改变是:多巴胺(DA)含量降低,去甲肾上腺素,5-羟色胺、γ-氨基丁酸和神经肽都有不同程度的减少。其主要临床症状,无动或少动、僵直、姿势异常、震颤等,都可归因于脑内DA 的缺乏,而治以左旋多巴或DA 拟似剂疗效显
Pathological changes in the brain have been well-known in patients who die from Parkinson’s disease (PD), primarily affecting the brain’s pigment nuclei, especially the substantia nigra pars compacta. However, non-catecholamines containing non-pigmented areas, such as the nameless band, can also be damaged. PD pathological changes are characterized by the presence of ewy bodies. Biochemical changes are: dopamine (DA) decreased, norepinephrine, 5-hydroxytryptamine, γ-aminobutyric acid and neuropeptides have varying degrees of reduction. The main clinical symptoms, no or less move, stiffness, postural abnormalities, tremor, etc., can be attributed to the lack of brain DA, and treated with levodopa or DA analog effect was