透明带(ZP)糖蛋白的组织特异性和在哺乳动物受精期间至关重要的作用,因而一直是研制避孕疫苗潜在的候选抗原。但用ZP蛋白主动免疫实现的避孕效果总是出现卵巢功能障碍问题,因此近年来许多研究开始尝试用ZP合成肽作为免疫原,以克服对卵巢严重的副反应。但是已有研究表明仅含单一 The tissue specificity of zona pellucida (ZP) glycoproteins and their crucial role during mammalian fertilization have been potential candidate antigens for the development of contraceptive vaccines. However, the contraceptive effect of active immunization with ZP protein is always the problem of ovarian dysfunction. Therefore, in recent years, many studies have begun to try to use ZP synthetic peptide as an immunogen to overcome the serious side effects on ovary. However, studies have shown that only a single