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研究前列腺素E_2(prostaglandin E_2,PGE_2)在胶原诱导性关节炎(collagen induced arthritis,CIA)小鼠体内的表达,并分析其与滤泡辅助性T细胞(follicular helper T cell,Tfh)之间的相关性。结果显示,与对照组相比,CIA小鼠血清前列腺素E代谢物(prostaglandin E metabolite,PGEM)浓度显著升高,小鼠脾脏和淋巴结中CD4~+CXCR5~+ICOS~+Tfh的比例、CD4~+Bcl-6~+Tfh的比例、CD4~+IL-21~+T细胞的比例均明显增高,且PGEM与上述细胞比例均呈正相关。该研究表明,CIA中PGE_2的表达与Tfh的比例存在正相关性。
To investigate the expression of prostaglandin E_2 (PGE_2) in collagen induced arthritis (CIA) mice and its relationship with follicular helper T cell (Tfh) Correlation. The results showed that compared with the control group, the concentration of prostaglandin E metabolite (PGEM) in CIA mice was significantly increased. The ratio of CD4 ~ + CXCR5 ~ + ICOS ~ + Tfh in spleen and lymph nodes, CD4 ~ + Bcl-6 ~ + Tfh, the ratio of CD4 ~ + IL-21 ~ + T cells were significantly increased, and PGEM and the proportion of cells were positively correlated. This study shows that there is a positive correlation between the expression of PGE_2 and the proportion of Tfh in CIA.