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目的：研究伊贝沙坦及苯那普利对中国高血压病患者肾素－醛固酮系统（ＲＡＳ）的影响．方法：轻中度高血压患者６１例，停用各种抗高血压药一周后，给予普通饮食及安慰剂两周。所有患者随机分成两组，分别口服伊贝沙坦１５０－３００ｍｇ，苯那普利 １０～２０ ｍｇ，每日一次。两周随访一次，记录血压和不良反应，疗程８周，治疗前后各行坐位取血，按照标准离心，用放免法检测肾素活性，血管紧张素几醛固酮。结果：服伊贝沙坦组肾素活性，血管紧张素Ⅱ呈平行性增加。苯那普利组好素活性升高，血管紧张素Ⅱ水平下降。醛固酮在两组中均轻度下降，但无统计学意义。伊贝沙坦和苯那普利的降压效果相似，伊贝沙坦组药物不良反应较少。结论：每日一次日服伊贝沙坦 １５０～３００ｍｇ或苯那普利 １０～２０ ｍｇ，，其降压作用相似均可持续２４ｈ。伊贝沙坦使血浆肾素，血管紧张素Ⅱ呈平行性升高，而苯那普利使肾素活性升高，血管紧张素Ⅱ水平下降，说明其作用机制不同；伊贝沙坦较苯那普利的副作用少是其选择性ＡＴ１受体阻制作用所致。
Objective: To investigate the effects of irbesartan and benazepril on renin-aldosterone system (RAS) in Chinese patients with hypertension. Methods: 61 cases of mild to moderate hypertension, disable various antihypertensive drugs after a week, giving the general diet and placebo for two weeks. All patients were randomly divided into two groups, respectively, oral irbesartan 150-300mg, benazepril 10 ~ 20 mg once daily. Two weeks follow-up, recording of blood pressure and adverse reactions, the course of treatment for 8 weeks, before and after treatment of various sitting blood, according to standard centrifugation, radioimmunoassay with renin activity, angiotensin aldosterone. Results: Serum renin activity of irbesartan group increased in parallel with angiotensin Ⅱ. Benazepril group good prime activity, angiotensin II levels decreased. Aldosterone in both groups were slightly decreased, but not statistically significant. Irbesartan and benazepril have similar antihypertensive effects, with fewer adverse events in the irbesartan group. Conclusion: Irbesartan 150 ~ 300mg daily or benazepril 10 ~ 20 mg daily, its antihypertensive effect can be sustained for 24h. Irbesartan plasma renin, angiotensin Ⅱ showed a parallel increase, while benazapril renin activity increased, decreased levels of angiotensin II, indicating that its mechanism of action; irbesartan than benzene Side effects of nalapx are few due to its selective AT1 receptor blockade.