目的观察氟米龙联合更昔洛韦治疗单疱病毒性角膜炎的疗效和安全性。方法选取医院收治的单疱病毒性角膜炎患者210例作为研究对象,根据治疗方式的不同随机分为对照组和观察组,每组105例。对照组采用更昔洛韦治疗,观察组采用氟米龙联合更昔洛韦治疗,比较2种治疗方案的临床疗效和安全性。结果观察组临床总有效率高达98.09%,显著高于对照组的83.81%(P<0.01);2组患者治疗过程中均未出现不良反应。结论单疱病毒性角膜炎患者采用更昔洛韦联合氟米龙治疗,临床疗效显著,安全可靠,值得推广应用。 Objective To observe the efficacy and safety of fluorometholone combined with ganciclovir in the treatment of herpes simplex virus keratitis. Methods A total of 210 patients with herpes simplex virus keratitis admitted to the hospital were enrolled in this study. According to the different treatment methods, they were randomly divided into control group and observation group, with 105 cases in each group. The control group was treated with ganciclovir. The observation group was treated with fluoromethonine and ganciclovir. The clinical efficacy and safety of the two treatment regimens were compared. Results The total clinical effective rate in the observation group was as high as 98.09%, significantly higher than that in the control group (83.81%, P <0.01). No adverse reactions occurred in the two groups during treatment. Conclusions Patients with herpes simplex virus keratitis treated with ganciclovir plus fluorometholone have significant clinical efficacy and safety, which is worthy of promotion and application.