骨髓增殖性肿瘤(myeloproliferative neoplasms,MPN)是一类起源于造血干细胞/祖细胞的克隆性疾病,经典的BCR-ABL1(-)MPN包括真性红细胞增多症(PPV)、原发性血小板增多症(ET)和原发性骨髓纤维化(PMF)。近年来发现炎症可以通过提供生物活性分子如细胞因子、生长因子、趋化因子浸润肿瘤微环境,促进肿瘤细胞持续增殖、抑制肿瘤细胞的凋亡、诱导基因组不稳定及 Myeloproliferative neoplasms (MPNs) are a group of clonal diseases that arise from hematopoietic stem / progenitor cells. Classical BCR-ABL1 (-) MPN includes polycythemia vera (PPV), essential thrombocythemia ET) and primary myelofibrosis (PMF). In recent years, it has been found that inflammation can infiltrate the tumor microenvironment by providing bioactive molecules such as cytokines, growth factors and chemokines, promote the continuous proliferation of tumor cells, inhibit tumor cell apoptosis, induce genomic instability and