拓扑异构酶的表达和数量的变化,导致细胞内物质和结构发生改变,进而使细胞的耐药性产生变化。本文就其在胃肠道肿瘤细胞中的表达及其抑制剂的作用机理进行综述。通过对抑制剂的作用分析,了解胃肠道肿瘤细胞的耐药性发生转变的特点和规律,从而为提高消化道实体肿瘤的临床化疗疗效提供理论依据。 Topoisomerase expression and quantitative changes, resulting in changes in the material and structure of the cell, thereby changing the cell resistance. This article reviews its expression in gastrointestinal tumor cells and its mechanism of action. Through the analysis of the effect of inhibitors, we can understand the characteristics and rules of the change of drug resistance of gastrointestinal cancer cells, and provide a theoretical basis for improving the clinical curative effect of solid tumors in gastrointestinal tract.