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目的 探讨胃癌拓扑异构酶 与 ki- 6 7表达的相关性。 方法 免疫组织化学方法研究 2 76例原发性胃癌拓扑异构酶 和 ki- 6 7标记指数的变化关系。 结果 弥漫型胃癌拓扑异构酶 和 ki- 6 7的标记指数明显高于肠型胃癌 ,拓扑异构酶 标记指数与 ki- 6 7标记指数呈明显的正相关 (r=0 .5 334 ,P<0 .0 5 ) ,但 ki- 6 7标记指数明显高于拓扑异构酶 的标记指数。 结论 拓扑异构酶 标记指数除可作为肿瘤患者抗药性指标外 ,还可作为肿瘤细胞增殖指数的指标 ,拓扑异构酶 表达量的高低与肿瘤的恶性转化有关
Objective To investigate the relationship between the expression of topoisomerase and Ki-67 in gastric cancer. Methods Immunohistochemical method was used to study the relationship between the changes of topoisomerase and ki-67 labeling index in 76 cases of primary gastric cancer. Results The index of topoisomerase and ki- 6 7 in diffuse gastric cancer was significantly higher than that in intestinal-type gastric cancer. The index of topoisomerase was positively correlated with the index of ki- 6 7 (r = 0.5344, P <0. 05), but the ki- 6 7 labeling index was significantly higher than the topoisomerase labeling index. Conclusion The topoisomerase labeling index can be used as an index of tumor cell proliferation index in addition to the drug resistance index of tumor patients. The expression level of topoisomerase is related to the malignant transformation of the tumor