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糖尿病视网膜病变(DR)是一种严重的致盲性眼病。醛糖还原酶(AR)是多元醇通路中的限速酶,而多元醇通路是机体组织细胞葡萄糖代谢的重要途径。多元醇通路中AR的激活与DR有着密切关系。AR可通过影响一氧化氮(NO)的生成、减少还原型谷胱甘肽(GSH)的含量、影响蛋白激酶C(PKC)和细胞信号传导及影响其他细胞因子如血管内皮细胞生长因子(VEGF)的活性等来影响DR的发
Diabetic retinopathy (DR) is a serious blinding eye disease. Aldose reductase (AR) is the rate-limiting enzyme in the polyol pathway, and the polyol pathway is an important pathway for glucose metabolism in the tissues and cells of the body. The activation of AR in polyol pathway is closely related to DR. AR can affect the production of nitric oxide (NO), reduce the content of reduced glutathione (GSH), affect protein kinase C (PKC) and cell signaling and affect other cytokines such as vascular endothelial growth factor ) Activity and so on to affect the development of DR