Co-delivery of doxorubicin and P-gp siRNA into human breast cancer cells by functionalized PLGA nano

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：linan9348

【摘要】

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【作者】

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Tingting Li Liwei Deng Min Xu Xue Shen Chunhui Wu Yiyao Liu

【机构】

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Department of Biophysics,School of Life Science and Technology,University of Electronic Science and

【出处】

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The Third Symposium on Innovative Polymers for Controlled De

【发表日期】

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2014年6期

【关键词】

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PLGA nanobubbles co-delivery P-gp siRNA doxorubicin ultrasound imaging

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　　Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy.One of the effective approaches to overcome MDR is to use nanoparticle-mediated gene silencing of chemotherapeutic export proteins by RNA interference to increase drug accumulation in drug resistant cancer cells [1,2].In this work,a new co-delivery system,DOX-PLGA/PEI/P-gp shRNA nanobubbles (NBs) around 427 nm,to overcome doxorubicin (DOX) resistance in MCF-7 human breast cancer was designed and developed.

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Co-delivery of doxorubicin and P-gp siRNA into human breast cancer cells by functionalized PLGA nano

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