【摘 要】
：
Conventional cell-penetrating peptides (CPPs)-mediated intracellular drug delivery systems are limited by lack of target selectivity.To solve this dilemma,tumor microenvironment stimulusresponsive nan
【机 构】
：
Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
Conventional cell-penetrating peptides (CPPs)-mediated intracellular drug delivery systems are limited by lack of target selectivity.To solve this dilemma,tumor microenvironment stimulusresponsive nanostructures have been introduced to build "off-on" switches to CPP activity based on sensitivity to external triggers (e.g.,light and temperature) or endogenous triggers (e.g.,enzymatic activity and pH).Light is an ideal external signal,which is non-invasive and can be well controlled.It was reported that 4,5-dimethoxy-2-nitrobenzyl chloroformate (Nvoc) is easily cleaved by UV radiation (365 nm) and photo-irradiation within 10 min was enough to induce the molecular fracture of labile 2-nitrobenzyl moieties,which impose little toxicity to cells but can trigger drug release [1].
其他文献
Dendrimers are highly branched,symmetrical macromolecules of nano-sized dimensions,consisting of a central core,repeating units and terminal functional groups.When used as drug nanocarriers,the dense
Recently,a substantial number of studies focused on gene therapy and nonviral gene delivery vectors [1,2].The REDV sequence is one of the main recognition sites for integrin a4βl binding,which leads t
A major bottleneck in cancer chemotherapy is to achieve specific drug accumulation at the tumor site.This obstacle can be potentially overcome by a targeted delivery approach using nanodelivery system
Widely recognized for their ability to produce a prolonged blood circulation time and facilitate tumor accumulation via the enhanced permeability and retention (EPR) effect,PEGylated liposomes hold gr
The successful cancer chemotherapy relies on the development of smart nanocarriers that are highly stable in circulation,preferentially accumulate in the tumor,are selectively taken up by cancerous ce
Modification of anti-cancer drugs with poly(ethylene glycol)(PEG),e.g.directly linking PEG to hydrophobic drugs and conjugating drugs to PEG-block copolymers (PEG-polyDeug),has been shown to significa
Herba Epimdii is a traditional Chinese medicine used for treatment of osteoporosis [1].The main pharmacological mechanisms were that epimedium flavonoids transformed into secondary glycosides or aglyc
Gene therapy is a promising approach to treat various human genetic and acquired diseases.Extensive efforts have been explored to increase gene transfection efficiency and low toxicity through rationa
Chemotherapy is one of the most promising therapeutic strategies in oncology,but the poisonous side effect and lack of targeting selectivity restrict their in-depth applications [1,2].The sustained dr
Polymeric micelles are under investigation as delivery vehicles for various anticancer drugs [1,2].However,these systems are rather unstable in the circulation leading to premature release of the load