2. 您的位置
3. 首页
4. 会议论文
5. Dual-sensitive charge-conversional polymeric prodrug for efficient co-delivery of demethylcantharidi

Dual-sensitive charge-conversional polymeric prodrug for efficient co-delivery of demethylcantharidi

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：yyttuuabc

【摘 要】

：

Tumor is a complicated system,and tumor cells are typically heterogeneous in many aspects[1].Polymeric drug delivery nano-carriers sensitive to a single type of bio-signals may not release cargos effe

【作 者】

：

Yanj uan Wu Dongfang Zhou Yubin Huang 

【机 构】

：

State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chine

【出 处】

：

Fourth Symposium on Innovative Polymers for Controlled Deliv

【发表日期】

：

2016年11期

【关键词】

：

dual-sensitive charge-conversion polymeric prodrug co-delivery drug resistance n 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Tumor is a complicated system,and tumor cells are typically heterogeneous in many aspects[1].Polymeric drug delivery nano-carriers sensitive to a single type of bio-signals may not release cargos effectively in all tumor cells,leading to low therapeutic efficacy[2].

其他文献

In situ forming polysaccharide based self-healing hydrogels for controlled release of cisplatin

Cisplatin is one of the most widely used anticancer agents[1].However,its therapeutic concentration is usually associated with dose-limiting side effects such as neurotoxicity,gastrointestinal disturb

会议

in situ forming hydrogelself-healingcontrolled releasecisplatin

Dual-functional LT-loaded reconstituted HDL designed based on median-effect principle for synergisti

Reconstituted high density lipoprotein (rHDL) displays dual functions in plaque targeting and anti-atherosclerosis.In our previous studies,cardiovascular drug tanshinone ⅡA (TA)-loaded rHDLs were prov

会议

high density lipoproteinatherosclerotic targetingdrug combinationmedian-effec

Preparation of injectable GelMA nanoparticles-based 3D printed wound healing filler

Implantable biomaterials can be applied to tissue engineering and drug delivery for sustained release of therapeutic molecules.However,the clinical implantation of biomaterials needs skilled physician

会议

GelMA nanoparticles3D printed technologyinjectable hydrogelwound healing fill

The eletrospinning of pH-sensitive 5-FU/RGO composite nanofibers and its potential application for t

Human colon cancer is one of the major causes of cancer death worldwide.The traditional therapy mainly focuses on surgical resection combined with chemotherapy.However,chemotherapy is often accompanie

会议

eletrospinninggraphene5-FUcolon cancer

Targeted co-delivery of dual-pronged cytotoxic agents with pH-responsive nanoparticle for synergisti

The complexity and heterogeneity of tumors have been increasingly concerned,which result in the undesirable antitumor efficacies of conventional chemotherapeutic drugs[1].Given the above background,th

会议

pH-responsive nanoparticletargetabilityintracellular drug co-deliverysynergis

Double-pulsatile release core-shell fibers fabricated using modified tri-axial electrospinning

Only around 100 kind of natural polymers can be directly electrospun into nanofibers,and of these only around 10 are suitable for use as pharmaceutical excipients.The ability of processing un-spinnabl

会议

tri-axial electrospinningcore-sheath nanofiberdouble-pulsatile releasepolymer

Reversible cross-linked micelles based on dynamic chemistry bond as potential nanocarriers for pH-tr

The convenience and flexibility in different chronic treatment regimes made the micellar vehicle a potential candidate for drug loading and injection treatment.Herein,two amphiphilic copolymers with s

会议

drug deliveryreversible cross-linked micellesdynamic chemistry bondstar topol

pH-Sensitive mixed micelles for overcoming drug-resistance and enhancing antitumor efficacy

Doxorubicin (DOX) is a widely used chemotherapeutic drug for the treatment of several types of cancers.However,its side effects and the development of multidrug resistance (MDR) greatly reduced the an

会议

multidrug resistanceP-glycoproteinTPGSDOX

Photo-crosslinked hollow capsules as platform for biomedical applications

Over the last years,huge efforts have been undertaken to develop feasible polymer-based systems for biomedical applications.Hollow capsules (e.g.polymersomes) among others have been proven to be promi

会议

hollow capsulesmembrane permeabilitypost-encapsulation-conjugationsynthetic

Smart pH-sensitive polymeric nanocarriers for combination chemotherapy

pH-sensitive polymeric nanocarriers look like the most promising tool for cancer therapy[1,2].In this work,novel pH-sensitive amphiphilic copolymers were firstly synthesized to facricate smart pH-sens

会议

smartpH-sensitivecombination chemotherapynanocarrierspoly(L-histidine)