MPP+相关论文
目的:近年来,肉碱/有机阳离子转运体1（Carnitine/organic cation transporter1,OCTN1）在中枢神经系统的生理作用逐渐被学者们关注,多......
研究背景帕金森病（Parkinson’s disease,PD）是一种以中脑黑质多巴胺（Dopamine,DA）神经元变性丢失为主要病理特征的神经退行性疾病。该......
目的 探讨在线粒体转录终止因子MTERF4在帕金森病细胞模型中的表达变化与机制.方法 以Mpp+诱导SH-SY5Y细胞,建立帕金森病细胞模型,......
目的 基于TrkB-CREB探讨白术(AM)对神经退行性疾病的神经保护作用.方法 首将温度诱导表达Aβ的AD模式秀丽隐杆线虫CL4176分为空白......
Acute Restraint Stress Augments 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurotoxicity via Incre
As an environmental risk factor,psychological stress may trigger the onset or accelerate the progression of Parkinson\......
Objective Estrogen (E2) has a wide neuroprotective effect on central nervous system (CNS) which related to the signaling......
Pinocembrin attenuates MPP +-induced neurotoxicity by the induction of heme Oxygenase-1 through ERK1
Our recent study demonstrated that pinocembrin (PB), the most abundant flavonoid in propolis, has neuroprotective effect......
1-methyl-4-phenylpyridinium ion induced csapase12 through Akt/glycogen synthase kinase-3b pathway in
1-methyl-4-phenylpyridinium ion (MPP+),an active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP),induc......
CpG methylation of alpha-Synuclein is regulated by 1-methyl-4-phenylpyridinium (MPP+) in dopaminergi
Parkinsons disease (PD) is a progressive neurodegenerative disease related to age, caused by degeneration of dopaminergi......
Thymoquinone protects SH-SY5Y cells against MPP+-induced oxidative stress by regulates Nrf2/ARE path
More and more evidence has shown that oxidative stress plays an important role in the pathogenesis of pakinsons disease ......
Neurotoxins are harmful to brain functions,especially interrupting memory processing.Hippocampal synaptic plasticity is ......
目的：氧化应激(Oxidative stress,OS)在PD的产生和发展中起着关键作用,Nrf2/HO-I是近年新发现的机体抵抗内外界氧化和化学等刺激的......
δ-Opioid receptor activation reduce hypoxia-and MPP+-induced α-synuclein overexpression and oligomer
We have previously demonstrated that δ-Opioid receptor (DOR) plays a crucial role in neuroprotection under both normoxi......
Myricetin attenuates MPP+-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK acti
Objective Increasing evidence suggests that oxidative stress may be implicated in the degeneration of dopaminergic neuro......
Up-regulated divalent metal transporter 1 by 1-Methyl-4-phenyl-pyridinium iodide (MPP+) enhances iro
Based on the previous study,we assume that newly discovered iron transporter,divalent metal transporter 1 (DMT1),might b......
Effects of tetrahydroxystilbene glucoside on MPP+-induced injury in A53T mutant a-synuclein transfec
Parkinsons disease (PD) is one of the most common neurodegenerative disorders.Several factors have been implicated as cr......
目的 研究5-羟基-1H-吲唑通过抑制Tau蛋白磷酸化对MPP+诱导凋亡的SH-SY5Y细胞的保护作用。方法 以MPP+诱导体外培养的SH-SY5Y细胞......
Chikusetsu Saponin V Attenuates MPP+-induced Neurotoxicity in SH-SY5Y Cells via Regulation of Sirt1/
Aim: Studies have shown that saponins from Panax japonicus (SPJ) possess neuroprotective effects.However, whether Chikus......
Parkinsons disease (PD) is the second most common neurodegenerative disease and afflicts almost 1.8％ of over 65-year-old ......
HDAC6 regulates aggresome-autophagy degradation pathway of α-synuclein in response to MPP+-induced s
Increasing evidence suggests that the ubiquitin-binding histone deacetylase-6 (HDAC6) plays an important role in the cle......
Neuroprotection by protocatechuic acid against MPP+-induced cytotoxicity in cultured neural stem/pro
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目的:通本研究采用PD 细胞和小鼠模型以及AD 转基因小鼠模型,应用行为学、形态学和分子生物学等手段,探讨姜黄素对神经元的保护作......
目的:探讨E3泛素连接酶(SIAH)在α-突触核蛋白(α-synuclein)降解和细胞死亡中的作用。方法:用MTT法检测雷帕霉素和SIAH-1抗体处理......
目的：考察1,2,3,4,6-O-五没食子酰基葡萄糖（1,2,3,4,6-penta-O-galloyl-β-D-glucose，β-PGG）对MPP＋诱导的帕金森病细胞模型中PC12细胞......
目的探讨黄芩苷是否通过上调长链非编码RNA(Long noncoding RNA,lncRNA)H19表达来减轻1-甲基4-苯基吡啶离子(1-methyl-4-phenylpyr......
探讨MPP+诱导SHSY5Y细胞凋亡的可能机制.采用流式细胞仪测定SHSY5Y细胞的凋l亡率、Bcl-2/Bax蛋白的表达率、活性氧的生成量,免疫细......
目的:研究特异性GSK-3β抑制剂Tideglusib对1-甲基-4-苯基-吡啶离子(1-methyl-4-phenylpyridinium ion,MPP+)诱导SH-SY5Y神经细胞......
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目的探究注射用脑蛋白水解物对大鼠肾上腺嗜铬细胞瘤（PC12）细胞增殖与1-甲基-4-苯基吡啶（MPP+）诱导的细胞氧化损伤的影响，为建立评价脑......
目的 探讨存活素(Survivin)能否抑制(1-甲基-4-苯基-吡啶离子(1-methyl-4-phenylpyridinium,MPP+)诱导的神经元(SH-SY5Y细胞)的凋......
[目的]探讨线粒体损伤与胰岛素信号传导之间的确切分子联系.[方法]用1-甲基-4-苯基-2,3-二氢吡啶离子(MPP+)抑制线粒体呼吸链复合......
目的探讨不同神经毒对N27细胞Caspase-3的影响。方法使用不同的神经毒素1-甲基-4-苯基吡啶离子(1-methyl-4-phenylpyridinium,MPP+......
为了探讨2,3,5,4’-四羟基二苯乙烯-2-ο-β-D-葡萄糖苷(2,3,5,4’-tetrahydroxystibene-2-ο-β-D-glucoside,TSG)对1-甲基-4-苯......
目的 观察银杏叶提取物 (EGb)对复制的在体及离体帕金森病 (PD)模型的保护作用 ,并探讨其作用机制。方法 1 Wista大鼠 4 0只 ,......
目的:探讨杨梅黄酮对MPP+处理的MES23.5细胞的保护作用。方法:实验分为空白对照组,MPP+处理组,MPP+和杨梅黄酮共处理组,分别处理ME......
目的:探讨咖啡酸苯乙酯(Caffeic Acid Phenethyl Ester,CAPE)对神经毒素诱导的帕金森病模型神经元损伤的保护作用。方法:体外用MPP......
目的考察1,2,3,4,6-O-五没食子酰基葡萄糖(1,2,3,4,6-penta-O-galloyl-β-D-glucose,β-PGG)对MPP+诱导的帕金森病细胞模型中PC12......
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第一部分Mpp+诱导PC12细胞凋亡的帕金森病细胞模型的建立应用3-(4 , 5-二甲基噻唑-2)-2 , 5-二苯基四氮唑溴盐法(3-(4,5)-dimethyl......
目的:探讨帕金森病(PD)模型细胞中p53、增殖细胞核抗原(PCNA)表达与细胞增殖、凋亡相关性及病理变化特征.方法:以不同浓度的1-甲基......
目的：探讨女贞子是否对Mpp＋诱导的PC12细胞氧化应激损伤具有保护作用.方法：采用Mpp＋诱导的PC12细胞作为帕金森病体外模型,同时给予不同......
【目的】观察姜黄素(curcumin,Cur)对MPP+诱导的PC12细胞凋亡的保护作用,并且探讨其与iNOS关系。【方法】采用碘化丙啶(PI)染色流......
目的 探讨Ndfip1对MPP+(1-甲基-4-苯基-1,2,3,6-四氢吡啶)诱导的帕金森病(Pkarkinsons disease,PD)细胞模型(人神经母细胞瘤SH-SY5......
目的 :观察硫丹 (ES)对培养的PC12 细胞增殖和形态学的影响及其诱导PC12 细胞凋亡作用。方法 :不同浓度MPP+ 和ES分别干预PC12 细......
目的:探讨人参皂甙Rg1对MPP+诱导SHSY5Y细胞凋亡的保护作用及其可能的机制.方法:用吖啶橙溴化乙锭染色观察SHSY5Y细胞凋亡率,流式......
目的探讨硫化氢对MPP＋诱导PC12细胞氧化应激损伤的保护作用。方法以MPP＋损伤PC12细胞作为帕金森病的细胞模型,甲氮甲唑蓝（MTT）法检测细......
