amyloid相关论文
Genetic variation in apolipoprotein E(APOE)influences Alzheimer\'s disease(AD)risk.APOE e4 alleles are the strongest g......
目的:研究黄芩素对Aβn 25-35损伤PC12细胞中谷氨酸受体相关蛋白表达的影响。n 方法:将PC12细胞按随机数字表法分为对照......
Parkinson\'s disease, the second most prevalent neurodegenerative disorder worldwide, is characterized by a progressiv......
The baker\'s yeast Saccharomyces (S.) cerevisiae is a single-celled eukaryotic modelorganism widely used in research o......
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Key Laboratory of Interfacial Physics and Technology,Shanghai Institute of Applied Physics,Chinese A
In the past years the self-assembly of amyloid-like peptides has attracted increasing attentions,because it is highly re......
Growth phase-dependent changes in the size and infectivity of SDS-resistant Sup35p assemblies associ
The translation termination factor Sup35p can form self-replicating fibrillar aggregates responsible for the [PSI+] prio......
Synergistic Inhibition of Amyloid Formation by Conjugates of Gold Nanoparticles and Rationally Desig
Amyloid formation plays a role in over 25 human disorders.Developing efficient inhibitors of amyloid formation has attac......
Many biological important processes are related to the conformation and assembly state of specific gene,involved protein......
Amyloid cross-seeding between Ab and hIAPP in relation to the pathogenesis of Alzheimer and type 2 d
Amyloid cross-seeding of different amyloid proteins is considered as a highly possible mechanism for exacerbating the tr......
Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain meta
Breast cancer brain metastases(BCBMs)are one of the most difficult malignancies to treat due to the intracranial locatio......
Marine diatoms construct their hierarchically ordered,three-dimensional(3D)external structures called frustules through ......
Effect of a Short Peptide with Alternating L-and D-Amino Acid on the Aggregation and Membrane Damage
Alpha-sheet is believed to be a significant structural compo-nent,formed in the fibrillation process of the amyloid pep-......
Concentration-Dependent Inuence of Silver Nanoparticles on Amyloid Fibrillation Kinetics of Hen Egg-
Understanding the inuence of nanoparticles on the formation of protein amyloid brillation is cru-cial to extend their ap......
The aggregation ofβ-amyloid(Aβ)protein into toxic intermediates and mature fibrils is considered to be one of the main......
The aggregation of β-amyloid (Aβ) protein into toxic intermediates and mature fibrils is considered to be one of the m......
目的探讨丙泊酚靶控输注联合七氟烷吸入维持麻醉对老年非小细胞肺癌（NSCLC）患者术后血清β-淀粉样蛋白（β-AP）、神经元特异性烯醇化酶（N......
<div style="text-align:justify;"> <span style="font-family:Verdana;"><strong>Background:</strong> The association of......
The murine microglial cell line BV2 has neuroprotective effects, but is toxic to neurons by secreting inflammatory cytok......
Neurodegenerative pathology can be seeded by introduction of misfolded proteins and peptides into the nervous system. Mo......
Aggregation of the amyloid β-peptide (A β) into insoluble fibrils is a key pathological event in Alzheimer's disea......
Pulmonary amyloidosis is uncommon and is usually associated with systemic amyloidosis. Localized pulmonary involvement i......
De novo intraocular amyloid deposition after hepatic transplantation in familial amyloidotic polyneu
The familiar amyloid polyneuropathy(FAP) is a rare autosomal-dominant systemic amyloidosis. Amyloid deposition occurs mo......
【定义】本病(amyloid diseases)是一组病因不同的疾患,其特点为各种组织内都有纤维样物质沉积,致使生命器官的功能受到影响,伴随......
早在1900年,Opie就发现糖尿病患者及老年人胰岛内有淀粉样蛋白沉积。1986～1987年Westermark等从胰岛淀粉样蛋白中分离出一种多肽,......
A new method has been proposed to realize the visual detection of D-amino acids(DAAs) via the antiaggregation of 4-merca......
Using blind dock method,we find that thioflavin-T(ThT) can bind to both monomers and fibrils of the full-length β-amylo......
Neuroprotective effect of the Chinese medicine Tiantai No.1 and its molecular mechanism in the senes
Tiantai No.1, a Chinese medicine predominantly composed of powdered Rhizoma Gastrodiae, Radix Ginseng, and Ginkgo leaf a......
3D-QSAR and docking studies on 2-arylbenzoxazole and linker-Y transthyretin amyloidogenesis inhibito
Transthyretin(TTR),a plasma protein with a tetramer structure,could form amyloid fibril associated with several human di......
Functional amyloid has been increasingly applied as self-assembling nanostructures to construct multifunctional biomater......
Background Amyloidosis is a collection of diseases in which different proteins are deposited·Amyloiddeposits occur in s......
β淀粉样蛋白(β-amyloid peptide,Aβ)是构成老年斑的主要成分,Aβ在阿尔茨海默病(Alzheimer’s disease,AD)的发生、发展中起主......
Based on the lead compound 1 reported in literature, a series of novel BACE1 inhibitors were designed and synthesized, a......
The assessment of nanomechanical properties of a single amyloid fibril in a confined space provides important informatio......
Neurodegenerative disease is one of the serious diseases of the human nervous system.There is no effective way to treat ......
It is crucial that maintain the insulin in solution in the monomer state to guarantee its physiological activity.Therefo......
PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of ty
OBJECTIVE Pioglitazone,known as a peroxisome proliferator-activated receptor γ(PPARγ) agonist,is used to treat type 2 ......
The toxicity of amyloid-beta(Aβ)is strongly associated with Alzheimer’s disease(AD),which has a high incidence in the ......
Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epi
In our previous studies, significant hypermethylation of the sirtuin 1(SIRT1) gene and demethylation of the b-amyloid pr......
Multiple myeloma (MM) is a malignancy of the plasma cell characterized by migration and localization to the bone marrow ......
The neuroendocrine hormone amylin, also known as islet amyloid polypeptide, is co-localized, co-packaged and cosecreted ......
Cardiac magnetic resonance imaging(CMRI) has emerged as a useful tertiary imaging tool in the investigation of patients ......
淀粉样沉积症是致命性的疾病,可以是神经退行性的,也可以是系统性的.该疾病以错误折叠蛋白质的堆积、缠绕成纤维为特征,最终导致受......
蛋白质二硫键异构酶由多种细胞分泌,在生物学代谢过程中具有重要作用,其与糖尿病缺血性心脏病、脑缺血性疾病、血栓性疾病、阿尔茨......
目的:研究Aβ_(25-35)引起乙酰胆碱酯酶高表达细胞株SC42凋亡与乙酰胆碱酯酶活性的关系。方法:用Aβ_(25-35)处理后,倒置相差显微......
Proteomic analysis of blood level of proteins before and after operation in patients with esophageal
AIM:To characterize the protein files in blood from same patients with esophageal squamous cell carcinoma(ESCC) before a......
