Alzheimer’s相关论文
The objective of the study was to explore the relationship between the indicators of Alzheimer’s disease and dementia w......
Despite many decades of researches and large numbers of clinical trials, there remain no effective treatments for Alzhei......
Virtual Cognitive Screenings and Interviews of Patients with Neurodegenerative Conditions Associated
The current pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), commonly referred to as COVID-19, ......
BACKGROUND The main clinical manifestation of Alzheimer’s disease(AD)is memory loss,which can be accompanied by neurops......
Evaluation of reporting quality of randomized controlled trials for cognitive interventions among Al
Background:The increasing number of Alzheimer’s Disease has become a global health issue.Whether randomized controlled ......
Alzheimer’s disease(AD)is one of the major life-threatening diseases for the elderly because neither pathogenesis nor e......
Alzheimer’s disease(AD)is a progressive and fatal neurodegenerative condition and the most prevalent cause of dementia.......
Alzheimer’s disease(AD)is the most common neurodegenerative disorder and there is currently no cure.Neural circuit dysf......
Comprehensive Management of Daily Living Activities,behavioral and Psychological Symptoms,and Cognit
Alzheimer\s disease(AD)is the most common cognitive disorder in the elderly.Its main clinical manifestations are cognit......
Evaluation of retinal and choroidal changes in patients with Alzheimer’s type dementia using optical
AIM:To evaluate the changes in fundus parameters in patients with Alzheimer’s type dementia(ATD)using optical coherence......
Assessment of causal effects of physical activity on neurodegenerative diseases:A Mendelian randomiz
Background:Physical activity has been hypothesized to play a protective role in neurodegenerative diseases.However,effec......
A significant public health concern with regards to increasing rates of Alzheimer’s is that it disproportionately affec......
Lithium has been used in the treatment of bipolar disorders for decades,but the exact mechanisms of action remain elusiv......
A new fluorescence at 333 nm formed when the solution of human neuronal tau protein was incubated at 37℃. The maximum e......
Alzheimer’s disease(AD) is a progressive neurodegenerative disorder and one of the most common causes of dementia in th......
Alzheimer’s disease affects millions of persons every year. Negative emotions such as stress and frustration have a neg......
目的：阿尔茨海默病（ AD）作为老年痴呆的一种主要类型，其特征为进行性认知功能障碍和记忆损害。本文旨在探索ZNF224基因（rs2061332，rs4508......
Impact of diabetes mellitus and cardiometabolic syndrome on the risk of Alzheimer’s disease among po
BACKGROUND In spite of an increase in the incidence and prevalence of diabetes mellitus(DM)and Alzheimer’s disease(AD)i......
As the population ages, Alzheimer’s disease is rapidly increasing, and the diagnosis of the disease is still poorly und......
Objective In the present study,the ABCA1 was used as a label to capture specific exosomes,the level of ABCA1-labeled exo......
Preventive effect of nasal Timosaponin BII-loaded temperature-/ionsensitive in situ hydrogels on Alz
Objective:To study the preventive effect of Timosaponin BII(T-BII)-loaded temperature/ion-sensitive nasal in situ hydrog......
Alzheimer’s disease(AD)is an age-related neurodegenerative disease with two major hallmarks:extracellular amyloid plaqu......
Cornel Iridoid Glycoside Suppresses Hyperactivity Phenotype in rTg4510 Mice through Reducing Tau Pat
rTg4510 mice are transgenic mice expressing P301L mutant tau and have been developed as an animal model of tauopathies i......
Senile plaques(SPs)are one of the pathological features of Alzheimer’s disease(AD)and they are formed by the overproduc......
Alzheimer’s disease(AD)is a chronic neurodegenerative disease that mainly causes dementia.It is a serious threat to the......
阿尔兹海默症(Alzheimer’s disease,AD)是伴有痴呆症的神经性退行性疾病最常见的形式。由β淀粉样蛋白(Aβ)组成的老年斑和由异常......
MicroRNA and mRNA profiling of cerebral cortex in a transgenic mouse model of Alzheimer’s disease by
In a previous study,we found that long non-coding genes in Alzheimer’s disease(AD)are a result of endogenous gene disor......
Sleep disorders are common in patients with Alzheimer’s disease,and can even occur in patients with amnestic mild cogni......
Dementia is a clinical syndrome that affects approximately 47 million people worldwide and is characterized by progressi......
The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and ......
Sporadic late-onset Alzheimer’s disease(SLOAD)and familial early-onset Alzheimer’s disease(FEOAD)associated with domin......
Proteolysis targeting chimera technology:a novel strategy for treating diseases of the central nervo
Neurological diseases such as stroke,Alzheimer’s disease,Parkinson’s disease,and Huntington’s disease are among the i......
In the central nervous system,immunologic surveillance and response are carried out,in large part,by microglia.These res......
High levels of the neurotoxic beta-amyloid protein (A<em>β</em>) in patients with Alzheimer’s disease present a signif......
目的探讨右美托咪定(dexmedetomidine,DEX)对APP/PS1转基因小鼠海马区抗炎抗凋亡的作用,并探讨其可能的机制。方法2018年3月至2019......
Background:To appraise the reporting quality of systematic reviews as well as meta-analyses of cognitive interventions a......
Amyloid beta peptides, tau protein acetylation and therapeutic strategies for treating Alzheimer’s d
Alzheimer’s disease(AD)is the most common progressive neurodegenerative disorder.It is often lethal and currently lacks......
本文分析了符合 CCMD—2诊断标准的10例阿尔采木氏病人的临床表现,描述了其临床特点,讨论了皮层损害综合征及气脑、CT 在确诊 AD ......
目的：观察Aβ1-42寡聚体对凋亡诱导因子（AIF）在神经细胞线粒体或细胞核中表达的影响。方法：将体外培养原代神经细胞分为对照组和Aβ1-4......
Autoantibodies in Alzheimer＇s disease： potential biomarkers, pathogenic roles, and therapeutic impli
Alzheimer’s disease(AD) is a prevalent and debilitating neurodegenerative disorder in the elderly.The etiology of AD ha......
Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease
The high metabolic demands of the brain require an efficient vascular system to be coupled with neural activity to suppl......
目的评估天王补心丹治疗老年痴呆患者睡眠障碍的效果,探讨白细胞介素（IL）-6、肿瘤坏死因子-α（TNF-α）在睡眠紊乱、认知减退中的作用。......
Enzyme-digested Colla Corii Asini(E’jiao) prevents hydrogen peroxide-induced cell death and accelera
As an aging-associated degenerative disease,Alzheimer’s disease is characterized by the deposition of amyloid beta(Aβ)......
Amyloid beta(Aβ)-induced neurotoxicity and oxidative stress plays an important role in the pathogenesis of Alzheimer’s......
Intrinsically disordered proteins, such as tau or α-synuclein, have long been associated with a dysfunctional role in n......
Neuroimaging mechanisms of high-frequency repetitive transcranial magnetic stimulation for treatment
Individuals with amnestic mild cognitive impairment(aMCI)have a high risk of developing Alzheimer’s disease.Although re......
Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood
Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many ......
Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta thr
Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzhe......
Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat mode
Melatonin can attenuate cardiac microvascular ischemia/reperfusion injury,but it remains unclear whether melatonin can a......
Modeling protein-protein interactions in axon initial segment to understand their potential impact o
The axon initial segment(AIS)region is crucial for action potential initiation due to the presence of high-density AIS p......
