QUINAZOLINE相关论文
为提高有机发光二极管的发光效率,设计合成了两种新的红光磷光双极性主体材料FC-CZ-PQZ和FC-BCz-PQZ,两种材料均表现出优秀的光物......
Quinazoline have been recognized as important heterocyclic compounds due to their diverse biological activities such as ......
The epidermal growth factor receptor(EGFR)is one important member of protein tyrosine kinases.Aberrant activation of EGF......
Lewis acid-catalyzed Formal [3+2] Cycloadditions of Quinazoline-3-N-oxides and Carbodiimide via Sele
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Synthesis of Quinazoline Derivatives via Copper-Catalyzed Domino Reaction of 2-Bromoaldehydes, Benzy
In recent years,aryl azides have emerged as powerful synthons and exhibited enormous potential in metal-catalyzed N atom......
CsOH-Mediated Aerobic Oxidative Cyclocondensation of 2-Aminoaryl Methanols and Nitriles for Facile S
Quinazoline derivatives are well studied in medicinal chemistry due to their pharmacological activities such as antioxid......
Synthesis,molecular modeling and biological evaluation of 4-alkoxyquinazoline derivatives as novel i
A series of novel quinazoline derivatives have been designed and synthesized,and their inhibitory activities have also b......
Synthesis,molecular modeling,and biological evaluation of quinazoline derivatives containing 1,3,4-o
A series of 4-alkoxyquinazoline derivatives containing 1,3,4-oxadiaxole scafifold have been designed and synthesized,and......
3D-QSAR and Phase Pharmacophore Analysis on Quinazoline EGFR Inhibitors, Insight from Water Involved
Water was found can bridge the binding between quinazolines and epidermal growth factor receptor (EGFR) through hydrogen......
In vitro anti-plasmodial activity of new synthetic derivatives of 1-(heteroaryl)-2-((5-nitroheteroar
Objective:To evaluate new compounds synthesized by integrating quinoline,quinazoline,and acridine rings with the active ......
采用具有喹唑啉为母核的抗肿瘤药物作为先导化合物,利用生物电子等排原理,设计并合成一系列4-(N-芳基)胺基-6-长链烷氧基取代蝶啶......
In vitro anti-plasmodial activity of new synthetic derivatives of 1-(heteroaryl)-2-((5-nitroheteroar
Objective: To evaluate new compounds synthesized by integrating quinoline, quinazoline, and acridine rings with the acti......
以4,5-二甲氧基-2-氨基苯甲酸和醋酸甲眯为起始原料,经环化、氯化、取代和缩合四步反应,设计、合成了六个未见文献报道的含有缩氨......
[BMIM]CI Catalyzed One-Pot Synthesis of α-Aminophosphonate Derivatives Containing a 4-Phenoxyquinazo
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Design, Synthesis and Bioactivities Evaluation of Novel Quinazoline Analogs Containing Oxazole Units
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
对Ｏ－（４－喹啉）羟肟酸硫代酯（酰胺）类化合物进行了合成及生物活性研究，部分化合物具有良好的抗病毒活性，超过商品化抗病毒剂ＤＨＴ，且稳定性很好。本文......
在作物的生长过程中常常会用到杀菌剂，为了寻找并筛选具有较高杀菌活性的化合物，本文利用生物等排原理及亚结构连接法，将具有优良生物......
Synthesis and anticancer effects of 6-nitro-4-anilinoquinazolines and 6-amino-4-ani-linoquinazolines
Objective: To synthesize inhibitors of the epidermal growth factor receptor tyrosine kinase such as 6-nitro-4-anilinoqui......
为了探讨化合物(2a~2c)合成工艺的影响因素,以6,7-二取代的喹唑啉酮(1a~1c)为起始原料,在催化剂(大孔树脂和三乙烯二胺)存在下,与......
4-芳胺基喹唑啉是十分有效的表皮生长因子受体（EGFR）抑制剂,是抗癌药物研制的热点之一.本研究以邻氨基苯腈、DMF-DMA、苯胺为原料,探......
以邻氨基苯甲酸、苯甲酸酐和乙酸为原料,经过绿色合成方法合成了2-苯基喹唑啉-4-酮,然后对2-苯基喹唑啉-4-酮进行了Vilsmeier反应......
４－氯喹唑啉与取代芳香肟在碱存在下进行亲核取代反应，合成了１７种新型肟醚基喹唑啉衍生物，并对其结构进行了表征。生物活性测试表明，部分化......
氨基喹唑啉类化合物具有良好的抗肿瘤活性,主要通过对表皮生长因子受体或其酪氨酸激酶的抑制作用,从而发挥抗癌的功效。综述了近年......
以4-氯喹唑啉和巯基化合物为原料，丙酮作溶剂，碳酸钾作缚酸剂，合成了7个新型4-硫醚基喹唑啉类化合物．采用1HNMR，13CNMR，IR及元素分析对目......
以喹唑啉-4-酮和溴苄为原料,在超声波辐射催化下,相转移催化两相合成N3-苄基喹唑啉-4-酮,化合物经IR和1HNMR确证了其结构。实验表......
在近些年发展中的农药进程中,由于喹唑啉类化合物的广谱生物活性和多变的结构类型,因此引起了广大人们的关注,也显示出了其广泛的......
采用具有喹唑啉为母核的抗肿瘤药物作为先导化合物,利用生物电子等排原理,设计并合成一系列4-(N-芳基)胺基-6-长链烷氧基取代蝶啶......
Quinolino[2,1-b]quinazolines 3 and 4, pyrrolo[2,1-b]quinazoline 5 and various substituted 2-(4-chlorostyryl)quinazoline ......
Quinolino[2,1-b]quinazolines 3 and 4, pyrrolo[2,1-b]quinazoline 5 and various substituted 2-(4-chlorostyryl)quinazoline ......
In silico pharmacokinetics studies can aid the search for molecules with potential ability to be drug candidates. In thi......
在对一系列抗癌性7，8-二烃基-1，3-二氨基吡咯-[3，2-f]喹唑啉类二氢叶酸还原酶抑制剂的二维定量构效关系（2D—QSAa）研究基础上，应用比较分......
