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观察含０．０７７ｎｍｏｌ／ｇＣｒ（Ⅲ）的富铬酵母对大鼠实验性高脂血症的防治作用，通过血脂、血铬及扫描电镜下主动脉内皮细胞超微结构的变化，探讨富铬酵母的降脂作用。结果表明，在给高脂饲料的同时按１８μｇＣｒ·ｋｇｂｗ（－１）．ｄ（－１）加入富铬酵母８０无后，大鼠ＴＣ、ＴＧ、ＬＤＬ－Ｃ增加值和ＨＤＬ－Ｃ、ＨＤＬ＿２－Ｃ下降值显著低于单纯食高脂饲料者。用本酵母１０μｇＣｒ·ｋｇｂｗ（－１）·ｄ（－１）治疗４０天后观察到，高血脂大鼠ＴＣ、ＴＧ、ＬＤＬ－ｃ显著下降，ＨＤＬ－ｃ、ＨＤＬ＿２－Ｃ、血清Ｃｒ显著上升，且效果优于月见草油。本文同时观察到，无论是用富铬酵母还是用月见草油来治疗，食基础饲料者比食高脂饲料者各项血脂水平均更接近于正常。从主动脉内皮细胞扫描电镜观察到，用本酵母预防８０天后大鼠病变较单纯食高脂饲料组轻。改用基础饲料同时食入富铬酵母的大鼠治疗后病变程度有所减轻，病变范围有所缩小。
To observe the preventive and therapeutic effects of Chromium-rich yeast containing 0.077nmol / g Cr (Ⅲ) on experimental hyperlipidemia in rats. The changes of ultrastructure of aortic endothelial cells under blood lipids, blood chromium and scanning electron microscope Lipid-lowering effect. The results showed that at the same time to give high-fat feed at 18μgCr · kgbw (-1). The added value of TC, TG, LDL-C and the decrease of HDL-C and HDL-C in rats fed with chromium-free yeast 80 d were significantly lower than those fed pure-fat diets alone. The TC, TG and LDL-c levels of hyperlipidemic rats were significantly decreased after treatment with 10μgCr · kgbw (-1) · d (-1) of the yeast for 40 days. HDL-c, HDL-2-C and serum Cr were significantly increased The effect is better than evening primrose oil. This article also observed, whether it is treated with chromium-rich yeast or evening primrose oil, basal diet than those fed high-fat diet, the blood lipid levels are closer to normal. From the aortic endothelial cells observed by scanning electron microscopy, with the yeast to prevent 80 days after the lesion in rats than the high-fat diet alone light group. Treated rats fed basal diet supplemented with chromium-rich yeast reduced the degree of lesion and reduced the extent of the lesion.