动物试验证实油剂博莱霉素(oil bleomycin)混悬液肿瘤内注射后,局部浓度高,维持时间比水剂博莱霉素长。此后博莱霉素油剂用于局部治疗皮肤肿瘤证明有良好疗效。一例70岁男性患者,在眉间长一疣状肿瘤,半年后肿瘤扩大,盖住整个眉间部,最后压迫右眼睑。检查时发现于眉间有一个5×3cm大小、圆的、菜花样的肿瘤,其表面大部糜烂,中央附有灰黄色痂,损害边缘硬。鼻受压后鼻孔变窄,肿瘤易出血,但局部淋巴结不肿大。实验室检查: Animal tests confirmed that the oily bleomycin (oil bleomycin) suspension after intratumoral injection, the local concentration is high, the maintenance time longer than the water bleomycin. Since then bleomycin oil for topical treatment of skin tumors have shown a good effect. A 70-year-old male patient with a verrucous tumor in his eyebrows grew his tumor half a year later, covering the entire interproximal eyebrow and finally pressing his right eyelid. Check found in the brow between a 5 × 3cm size, round, cauliflower tumor, most of its surface erosion, the center with a gray scab, damage to the edge of the hard. Nasal narrowing of the nose after compression, the tumor is easy to bleeding, but local lymph nodes are not enlarged. Laboratory examination: