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多发性硬化(MS)的病理特征为脱髓鞘,轴突相对完好,炎症和胶质增生。一个重要的问题是MS病损谁先受累,是炎症引起血脑屏障(BBB)破坏在先脱髓鞘在后,还是原发性脱髓鞘刺激而导致炎症性BBB渗漏,为此,作者采用每周一次钆强化T_1加权MRI和MT成像连续观察与MS相关的系列变化特征。所有病例或为复发缓解型MS,或为继发性进行性MS。11例中3例(1例复发缓解,2例进行性MS)显示钆强化病灶符合研究标准。3例完成了全部研究,出入院用EDSS或Kurtzke′s功能评分法评估。所有成像均用标准头线圈1.5T超导系统。首先精确定位选层行T_1WI(矢状面、横断面、冠状面)。最初MRI评估用自旋回波序列(TR=500ms,TE=14ms,层厚5mm,2次激发,视窗24cm,矩阵256×128)。
The pathological features of multiple sclerosis (MS) are demyelination, relatively intact axons, inflammation and glial proliferation. An important question is whether the MS lesion is involved first, whether the blood-brain barrier (BBB) damage caused by inflammation is demyelinated first, or primary demyelinating stimulation leading to inflammatory BBB leakage. To this end, the author Continuous gadolinium-enhanced T-1-weighted MRI and MT imaging were used to observe serial changes associated with MS. All cases were either relapsing-remitting MS or secondary progressive MS. Three of the 11 patients (1 relapsed and 2 MS progressive) showed gadolinium-enhanced lesions that met the criteria of the study. All three completed the study, and admission was assessed using the EDSS or Kurtzke’s functional rating scale. All imaging uses a standard head coil 1.5T superconducting system. First of all, select the T_1WI (sagittal plane, transverse plane, coronal plane). Initial MRI evaluations were performed with spin echo sequences (TR = 500 ms, TE = 14 ms, layer thickness 5 mm, 2 shots, window 24 cm, matrix 256 × 128).