目的通过对凝胶剂的体外累计释放百分率的比较,优化伊曲康唑凝胶剂的处方。方法选用卡波姆-940作为凝胶剂的基质,用3种不同质量分数的伊曲康唑(ITZ)、甘油、PEG-400制备凝胶剂。采用Franz扩散池进行体外释放实验,正交设计优选处方。结果优选的凝胶剂最佳处方为:ITZ质量分数为1%、PEG-400质量分数为10%、甘油质量分数为5%。结论体外累积释放试验筛选伊曲康唑凝胶剂处方是可行的。 OBJECTIVE To optimize the formulation of itraconazole gel by comparing the cumulative cumulative percentage release of gel in vitro. Methods Carbomer-940 was used as the matrix of gels, and gels were prepared with 3 different ITZ, glycerol and PEG-400. The Franz diffusion cell was used for in vitro release experiments and the orthogonal design was optimized. Results The best prescription of gel was 1% ITZ, 10% PEG-400 and 5% glycerol. Conclusion In vitro cumulative release test screening of itraconazole gel formulations is feasible.