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目的 :探讨胃粘膜血流量与慢性萎缩性胃炎 (CAG)的关系以及运用愈胃灵治疗 CAG后胃粘膜血流量的改变。方法 :应用激光多普勒血流仪 ,对 35例 CAG患者及 30例慢性浅表性胃炎 (CSG)患者进行胃粘膜血流的测定。结果 :与 CSG相比 ,CAG患者的胃粘膜血流量值呈低下状态 ;运用中药愈胃灵治疗后 ,胃粘膜病理改变均得到改善。并对其中 14例 CAG患者 ,作胃粘膜血流变化的自身对照 ,胃粘膜血流量值均有不同程度的提高 (P<0 .0 1)。结论 :胃粘膜微循环灌注量不足是 CAG发病机制中不可忽视的环节 ,愈胃灵可以提高胃粘膜的血流量 ,为粘膜的修复提供了良好环境。
Objective: To investigate the relationship between gastric mucosal blood flow and chronic atrophic gastritis (CAG) and the change of gastric mucosal blood flow after CAG treatment. Methods: Gastric mucosal blood flow was measured in 35 patients with CAG and 30 patients with chronic superficial gastritis (CSG) by laser Doppler flowmeter. Results: Compared with CSG, the gastric mucosal blood flow in CAG patients was in a low state. The pathological changes of gastric mucosa were all improved after treatment with Chinese herbal medicine. In 14 CAG patients, the blood flow of gastric mucosa was increased to some extent (P <0.01). CONCLUSION: Inadequate perfusion of microcirculation in gastric mucosa can not be neglected in the pathogenesis of CAG. Guanerling can improve gastric mucosal blood flow and provide a good environment for mucosal repair.