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目的：研究ｐ１６蛋白在膀胱移行细胞癌组织中的表达意义。方法：应用免疫组织化学ＬＳＡＢ法检测４０例膀胱移行细胞癌组织中ｐ１６蛋白的表达。结果：４０例膀胱移行细胞癌中ｐ１６蛋白的阳性表达率为４５％，ｐ１６蛋白的表达与肿瘤的病理分级、临床分期及患者的生存率显著相关（Ｐ＜０．０１，Ｐ＜０．０５）。结论：对膀胱移行细胞癌患者进行ｐ１６蛋白的检测，对于判断肿瘤的恶性程度、自然病程及预测预后有一定的指导作用和临床应用前景
Objective: To study the expression of p16 protein in bladder transitional cell carcinoma. Methods: The expression of p16 protein in 40 cases of bladder transitional cell carcinoma was detected by immunohistochemistry LSAB method. Results: The positive rate of p16 protein was 45% in 40 cases of bladder transitional cell carcinoma. The expression of p16 protein was significantly correlated with the pathological grade, clinical stage and survival rate of patients (P <0.01, P <0.05) ). Conclusion: The detection of p16 protein in patients with transitional cell carcinoma of the bladder has some guiding significance and clinical application prospects in judging the malignant degree, natural history and prognosis of the tumor