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核基质（ｎｕｃｌｅａｒｍａｔｒｉｘ，ＮＭ）是真核细胞核内的非组蛋白网架结构，与肿瘤的发生密切相关〔１〕。肿瘤细胞具有特异性核基质蛋白（ｎｕｃｌｅａｒｍａｔｒｉｘｐｒｏｔｅｉｎ，ＮＭＰ），因此，制备肿瘤特异性ＮＭＰ的ｍＡｂ具备潜在的应用价值〔２〕。但ＮＭ?
Nuclear matrix (NM) is a non-histone protein network structure in the nucleus of eukaryotic cells and is closely related to tumorigenesis [1]. Tumor cells have specific nuclear matrix protein (NMP), so the preparation of tumor-specific NMP mAb has potential application value [2]. But NM?