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用同种胰腺组织加Freund氏佐剂免疫8只大白鼠后35天,免疫组空腹血糖(90.1±14.6mg/dl)与正常对照组空腹血糖(91.3±13.8mg/dl)无显著差异;免疫组空腹血浆胰岛素(40.69±9.73μIU/ml)与正常对照组空腹血浆胰岛素(40.11±10.96μIU/ml)亦无显著差异;病理学检查表明免疫组大鼠胰岛结构正常,无炎症及淋巴细胞浸润,提示同种免疫未能造成大鼠胰岛功能损伤。
35 days after immunization of 8 rats with the same kind of pancreatic tissue plus Freund’s adjuvant, the fasting blood glucose (90.1 ± 14.6 mg / dl) in the immunized group was no significant difference compared with the normal control group (91.3 ± 13.8 mg / dl) The fasting plasma insulin (40.69 ± 9.73μIU / ml) and the fasting plasma insulin (40.11 ± 10.96μIU / ml) of the normal control group also showed no significant difference. The pathological examination showed that the islet structure of the immunized group was normal without inflammation and lymphocyte infiltration , Suggesting that alloimmunization failed to cause rat pancreatic islet function damage.