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本文报道了雨蛙肽对半胱胺诱发大鼠十二指肠溃疡的影响。实验结果表明,预先肌肉注射雨蛙肽20ng/kg体重,可明显地减轻半胱胺所诱发的大鼠十二指肠溃疡,其损伤记分均值与对照组相比有显著差异(P<0.025),而10ng/kg体重剂量的雨蛙肽,则均无明显的影响(P>0.05)。结果提示一定剂量(20ng/kg)的雨蛙肽对半胱胺诱发的大鼠十二指肠溃疡,具有一定的细胞保护作用。这种保护作用被消炎痛(5mg/kg)所阻止。
This paper reports the effects of cerulein on cysteamine-induced duodenal ulcer in rats. The experimental results showed that intramuscular injection of cerulein 20 ng/kg body weight significantly reduced cysteamine-induced duodenal ulceration in rats, and the average score of lesion scores was significantly different from that of the control group (P<0.025). The 10 ng/kg body weight dose of the frogs had no significant effect (P>0.05). The results suggest that a certain dose (20ng/kg) of cerulein has certain cytoprotective effect on cysteamine-induced duodenal ulcer in rats. This protection was prevented by indomethacin (5 mg/kg).