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半胱胺可以引起大鼠体内生长抑素耗竭并诱发十二指肠溃疡。本工作发现,腹腔注射牛胰多肽可以减轻半胱胺引起的大鼠十二指肠溃疡,还可防止半胱胺引起的大鼠十二指肠粘膜生长抑素含量的下降。这项工作提示,牛胰多肽可能通过防止局部生长抑素的耗竭对十二指肠起到保护作用。
Cysteamine can cause somatostatin depletion and induce duodenal ulcer in rats. This work found that intraperitoneal injection of bovine pancreatic polypeptide can reduce cysteamine-induced duodenal ulcer rats, but also to prevent cysteamine-induced decline in duodenal mucosal somatostatin levels. This work suggests that bovine pancreatic polypeptide may play a protective role in the duodenum by preventing the depletion of somatostatin.