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本文以家兔急性实验性血清病为模型,用环孢菌素A(CyA)于抗原诱导早期和晚期分别处理家兔。发现早期或晚期用药均可以降低家兔特异性抗体和IC水平,减少补体消耗,抑制溶酶体酶释放和肾小球内单核细胞浸润,最终减轻肾脏病变。但早期用药效果优于晚期。本文进一步证实了T细胞在免疫复合物型肾小球肾炎发病中可能起介导作用,单核细胞浸润与肾脏的病理损伤密切相关,提出CyA不仅对于刚建立的免疫反应有抑制作用,而且影响疾病的进程。
In this study, a rabbit model of acute experimental serum disease was used to treat rabbits with cyclosporin A (CyA) at the early and late stages of antigen induction. Early or late drug use was found to reduce rabbit specific antibody and IC levels, reduce complement consumption, inhibit lysosomal enzyme release, and monocyte mononuclear cell infiltration, and ultimately reduce renal disease. However, the effect of early medication is better than that of late. This article further confirmed that T cells may play a role in the pathogenesis of immune complex glomerulonephritis. Monocyte infiltration is closely related to the pathological damage of the kidney. It is proposed that CyA not only has an inhibitory effect on the newly established immune response, but also affects The course of the disease.