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目的:探讨肝细胞肝癌(hepatocellular carcinoma,HCC)组织中14-3-3zeta蛋白的表达及其临床意义。方法:采用免疫组织化学染色法检测134例HCC组织中14-3-3zeta表达,并分析14-3-3zeta的表达与临床相关特征的关系。结果:14-3-3zeta在HCC组织表达升高,癌组织中14-3-3zeta蛋白表达阳性率为56.72%(76/134),显著高于癌旁组织18.03%(22/122),差异有统计学意义,P<0.01。14-3-3zeta在炎性细胞浸润的癌组织中表达阳性率为73.53%(25/34),显著高于无炎性细胞浸润癌组织50.52%(49/97),差异有统计学意义,P=0.020。14-3-3zeta表达水平与TNM分期、分化程度以及肿瘤大小无相关性。结论:HCC癌组织中14-3-3zeta蛋白表达显著高于癌旁组织,同炎性细胞的浸润相关,提示14-3-3zeta可能在HCC免疫应答中起到一定的作用。
Objective: To investigate the expression of 14-3-3zeta protein in hepatocellular carcinoma (HCC) tissues and its clinical significance. Methods: The expression of 14-3-3zeta in 134 HCC tissues was detected by immunohistochemical staining. The relationship between the expression of 14-3-3zeta and clinically relevant features was analyzed. Results: The expression of 14-3-3zeta in HCC tissues was increased. The positive rate of 14-3-3zeta protein expression in cancer tissues was 56.72% (76/134), significantly higher than that in adjacent tissues (18.03%, 22/122) There was statistical significance (P <0.01). The positive expression rate of 14-3-3zeta was 73.53% (25/34) in inflammatory cell infiltration, which was significantly higher than that in non-infiltrating inflammatory cell carcinoma (50.52%, 49.5% 97), the difference was statistically significant, P = 0.020.14-3-3zeta expression level and TNM staging, differentiation and tumor size no correlation. Conclusion: The expression of 14-3-3zeta protein in HCC tissues is significantly higher than that in paracancerous tissues, which is related to the infiltration of inflammatory cells, suggesting that 14-3-3zeta may play a role in the immune response of HCC.