末端炔烃是有机合成中重要的原料或中间体.通过钯催化的Sonogashira偶联反应,将2-甲基-3-丁炔-2-醇连接到其它基团上所得到的结构,可以看作是一类丙酮保护的末端炔烃.目前,对于这种丙酮保护的末端炔烃,其去保护得到端基炔主要是通过KOH存在下在甲苯中回流数小时的方法,但是反应温度高,条件苛刻,适用范围较窄.对这一脱保护过程进行研究,通过对多种溶剂和反应温度进行对比,发现以1,4-二氧六环作为溶剂,KOH作为碱,可以在相对较低的温度(60℃)下得到较高的产率,而且所需时间大大缩短(0.5~2 h),拓展了这种方法的应用范围. Terminal alkynes are important starting materials or intermediates for organic synthesis The structures obtained by attaching 2-methyl-3-butyn-2-ol to other groups via palladium-catalyzed Sonogashira coupling reactions can be seen As a class of acetone-protected terminal alkynes.At present, for the acetone-protected terminal alkyne, its deprotection to obtain terminal alkyne is mainly refluxed for several hours in toluene by the presence of KOH, but the reaction temperature is high, Harsh conditions, the scope of application is narrow.This deprotection process is studied by comparing a variety of solvents and the reaction temperature and found that 1,4-dioxane as a solvent, KOH as a base, can be relatively low (60 ℃), and the required time is shortened (0.5 ~ 2 h), which expands the application range of this method.