药物所致的急性小管间质性肾炎,常表现为不同程度的急性肾衰,而持续活动的间质病变也可引起肾功能缓慢的改变,最终导致慢性或终末期肾衰。本文旨在讨论系统性疾病及电介质紊乱时所发生的慢性小管间质性病变。电介质紊乱时小管间质性肾炎一、低钾血症 1.病理生理:低钾血症除药物所致外,晚近报道存在与HLA相关的家族性低钾血症性间质性肾炎。它与小管膜的缺陷有关,常 Drug-induced acute tubulointerstitial nephritis, often manifested as varying degrees of acute renal failure, and persistent interstitial lesions can also cause slow changes in renal function, eventually leading to chronic or end-stage renal failure. The purpose of this article is to discuss chronic tubulointerstitial lesions that occur with systemic and dielectric disorders. Tubulointerstitial nephritis dielectric disturbance 1, hypokalemia 1. Pathophysiology: hypokalemia in addition to the drug, the recent reports of HLA-associated familial hypokalemia interstitial nephritis. It is related to the defects of the tunic membrane, often