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目的 提高胰腺内分泌肿瘤的诊疗水平。方法 回顾性分析 2 3例胰腺内分泌肿瘤病人的临床资料。结果 胰腺内分泌肿瘤以胰岛素瘤、非功能性胰岛细胞瘤及胃泌素瘤最为常见 ,肿瘤大小与症状轻重无关。该组胰岛素瘤均为良性 ,其它 6 0 %为恶性。血管造影、门静脉血激素水平测定及术中B超对胰岛素瘤的诊断阳性率分别为 6 7%、83%及 10 0 %。胰岛素瘤均行肿瘤摘除术 ;胃泌素瘤及MEN -Ⅰ因合并症急诊行全胃切除术 ;胰高血糖瘤行姑息切除术 ;非功能性胰岛细胞瘤恶性者因局部浸润及转移未予解除。结论 除非功能性胰岛细胞瘤外 ,胰腺内分泌肿瘤多有完整被膜 ,可行摘除手术 ,姑息切除亦可明显缓解症状。即使为恶性 ,预后亦好于胰外分泌肿瘤。
Objective To improve the diagnosis and treatment of pancreatic endocrine tumors. Methods The clinical data of 23 patients with pancreatic endocrine tumors were retrospectively analyzed. Results In pancreatic endocrine tumors, insulinoma, non-functioning islet cell tumor, and gastrinoma were the most common. The size of the tumor was not related to the severity of symptoms. The insulinomas in this group were all benign, and the other 60% were malignant. The angiographic and portal venous hormone levels and intraoperative B-ultrasound diagnosis of insulinoma were positive in 7%, 83%, and 100%, respectively. Insulinoma undergone tumor removal; Gastrinoma and MEN-I due to complications for emergency total gastrectomy; Pancreatic hyperglycoma for palliative resection; Nonfunctioning islet cell tumor malignant due to local infiltration and metastasis Lifted. Conclusions Except for functional islet cell tumors, pancreatic endocrine tumors usually have intact capsules, feasible removal surgery, and palliative resection can significantly relieve symptoms. Even if it is malignant, the prognosis is better than that of pancreatic cancer.