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性连锁基因和表型可以通过它们在家系中特有的遗传方式定位于X染色体上,这对常染色体顺序是不可能的,所以X染色体基因图成为所有人类染色体中研究得最广泛的.X染色体上至少有100个疾病位点和100个DNA标记已经定位.几年前,X染色体上只有两个连锁群,一个在Xpter区域,另一个在Xqter区域.通过限制性片段长度多态性(RFLP)作为遗传标记的应用,现在完整的X染色体图几乎形成.这些遗传标记沿着整个X染色体分布使得任何性连锁疾病的制图都是可能的.
Sex-linked genes and phenotypes can be located on the X chromosome by their unique inheritance in the pedigree, which is not possible with autosomal sequences, so the X chromosome map is the most studied of all human chromosomes. The X chromosome There are at least 100 disease sites and 100 DNA markers that have been mapped in. A few years ago, there were only two linkage groups on the X chromosome, one in the Xpter region and the other in the Xqter region. By restriction fragment length polymorphism (RFLP ) As a genetic marker application, complete X-chromosome maps are now almost established, and the distribution of these genetic markers along the entire X chromosome makes possible the mapping of any sex-linked disease.