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Interleukin-12(IL-12) is a critical cytokine representing the link between the cellular and humoral branches ofhost immune defense apparatus.IL-12-induced cytotoxic lymphocyte(CTL) development is a centralmechanism in immune responses against intracellular infectious agents as well as malignant growth.However,the molecular basis of tumor-specific CTL responses mediated by IL-12 remains poorly defined.In this study,we addressed this issue in a comprehensive manner to probe into IL-12-induced anti-tumor responses by globalgene expression profiling of mRNA expression in CD8~+ T cells in a transplantable syngeneic mouse mammarycarcinoma model treated or not with recombinant IL-12.A strong tumor regression was induced by the IL-12treatment.An introspection of differential gene expression at an early stage of the IL-12-initiated CTLactivation reveals interesting genes and molecular pathways that may account for the marked tumor regression,and is likely to provide a rich source of potential targets for further research and development of effectivetherapeutic modalities.Cellular & Molecular Immunology.2004;1(5):357-366.
Interleukin-12 (IL-12) is a critical cytokine presenting the link between the cellular and humoral branches ofhost immune defense apparatus. IL-12-induced cytotoxic lymphocyte (CTL) development is a centralmechanism in immune responses against intracellular infectious agents as well as malignant growth. Although the molecular basis of tumor-specific CTL responses mediated by IL-12 remains poorly defined. In this study, we addressed this issue in a comprehensive manner to probe into IL-12-induced anti-tumor responses by globalgene expression profiling of mRNA expression in CD8 ~ + T cells in a transplantable syngeneic mouse mammarycarcinoma model treated or not with recombinant IL-12.A strong tumor regression was induced by IL-12 treatment. Ann introspection of differential gene expression at an early stage of the IL-12-initiated CTL activation focusing interesting genes and molecular pathways that may account for the marked tumor regression, and is likely to provide a rich source of potential t argets for further research and development of effective therapeutic modalities. Cellular & Molecular Immunology. 2004; 1 (5): 357-366.