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采用随机、对照、单盲法观察川芎嗪对硝酸甘油耐药的拮抗作用。 60例不稳定型心绞痛患者随机分为空白对照组、血管紧张素转换酶抑制剂 (ACEI)组及川芎嗪组。 3组均以硝酸甘油 (NTG)持续静脉滴注 2 4h作为基础治疗 ,ACEI组服开搏通 1 2 .5mg,2次 ,川芎嗪组静滴川芎嗪 1 .6mg/kg,2次 ,观察临床症状、收缩压变化并测定血浆一氧化氮 (NO)、脂质过氧化物 (LPO)、超氧化物歧化酶 (SOD)、内皮素(ET)、血管紧张素Ⅱ (AngⅡ )的水平。结果显示 ,在NTG静滴过程中发生了耐药现象 ;川芎嗪与开搏通均有抗耐药作用 ,两组分别与空白对照组比较 ,均有显著性差异 (P <0 .0 5) ;川芎嗪组与ACEI组比较 ,无显著性差异 (P >0 .0 5)。川芎嗪可能通过对抗氧自由基而发挥其拮抗效应。
A randomized, controlled, single-blind method was used to observe the antagonistic effect of tetramethylpyrazine on nitroglycerin resistance. Sixty patients with unstable angina were randomly divided into control group, angiotensin-converting enzyme inhibitor (ACEI) group, and tetramethylpyrazine group. All three groups were treated with continuous intravenous infusion of nitroglycerin (NTG) for 24 hours. The ACEI group received 12.5 mg of captopril, 2 times, and the tetramethylpyrazine group received 6.2 mg/kg of tetramethylpyrazine for 2 times. Changes in clinical symptoms, systolic blood pressure, and levels of plasma nitric oxide (NO), lipid peroxide (LPO), superoxide dismutase (SOD), endothelin (ET), and angiotensin II (AngII). The results showed that drug resistance occurred during the infusion of NTG; Tetramethylpyrazine and captopril had anti-drug resistance, and there were significant differences between the two groups compared with the blank control group (P<0.05). There was no significant difference between the tetramethylpyrazine group and the ACEI group (P > 0.05). Ligustrazine may exert its antagonistic effect by fighting oxygen free radicals.