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HD治疗的患者常导致脂质代谢异常,并有较高的心脑血管疾病发病率.我们检测了经HD治疗后72例慢性肾衰患者(CRF)血清载脂蛋白(a)及其它脂质水平,分析了脂质异常的原因。经与190例健康人比较,发现载脂蛋白(a)表型在HD组和对照组中的整体构成比差异不大(P>0.5),但表型B在HD组中出现的频率明显高于对照组(P<0.05).另外,HD组甘油三酯和脂蛋白(a)浓度亦明显高于对照组(P<0.001),高密度脂蛋白胆固醇和载脂蛋白Al,浓度明显低于对照组(P<0.001),其它脂质在两组间的差别不显著(P>0.5)。
HD patients often lead to abnormal lipid metabolism and have a high incidence of cardiovascular and cerebrovascular diseases.We examined the serum levels of apolipoprotein (a) and other lipids in 72 patients with chronic renal failure (CRF) after HD treatment Level, analyzed the causes of lipid abnormalities. Compared with 190 healthy subjects, it was found that the overall composition ratio of apolipoprotein (a) in HD group and control group was not significantly different (P> 0.5), but the frequency of phenotype B in HD group was significantly higher (P <0.05) .In addition, the concentrations of triglyceride and lipoprotein (a) in HD group were also significantly higher than those in control group (P <0.001), the concentrations of HDL-C and AP were significantly lower than those in control group In the control group (P <0.001), there was no significant difference in other lipids between the two groups (P> 0.5).