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采用ＥＬＩＳＡ法检测２５７７例妊娠早期妇女血清中的人巨细胞病毒（ＨＣＭＶ）特异性抗体，对ＨＣＭＶ－ＩｇＭ阳性者应用聚合酶链反应（ＰＣＲ）检测胎儿附属物中的ＨＣＭＶＤＮＡ，将其中ＨＣＭＶＤＮＡ阳性的９９例视为感染组，阴性者９３例为对照组。采用不同的监测方法动态现在两组胎儿宫内及分娩时的状况，以及出生后２～３０个月婴幼儿的生长发育情况。结果显示：感染组死胎、畸形、宫内发育迟缓、新生儿窒息等的发生率均高于对照组（均为Ｐ＜０．０５），而新生儿平均身高、体重均低于对照组（均为Ｐ＜０．０５）；婴幼儿期感染组中头颅超声、脑干听觉诱发电位（ＢＡＥＰ）的异常率明显高于对照组（均为Ｐ＜０．０５），智力发育指数的平均值明显低于对照组（Ｐ＜０．０１）；说明先天性ＨＣＭＶ感染与出生缺陷，婴幼儿期神经系统、智力发育迟缓，听力障碍等有密切关系。
Serum samples of 2577 pregnant women with HCMV were detected by ELISA. HCMV DNA was detected by polymerase chain reaction (PCR) in HCMV-IgM-positive women. 99 cases were regarded as infection group, 93 cases were negative as control group. Different monitoring methods are used to dynamically present the status of the fetus and childbirth in both groups and the growth and development of infants and toddlers at 2 to 30 months after birth. The results showed that the incidence of stillbirth, deformity, intrauterine growth retardation and neonatal asphyxia in the infection group were higher than those in the control group (all P <0.05), while the average height and weight of newborns were lower than those of the control group P <0.05). The abnormal rates of cranial ultrasound and brainstem auditory evoked potential (BAEP) in infants and young children were significantly higher than those in the control group (all P <0.05), and the average value of mental development index was significantly Lower than the control group (P <0.01); that congenital HCMV infection and birth defects, infantile nervous system, mental retardation, hearing disorders are closely related.