论文部分内容阅读
为探讨前列腺癌（PCa）细胞转移的机制，应用免疫组织化学SP法在36例良性前列腺增生（BPH）及34例PCa组织中对第Ⅷ因子相关抗原进行表达，计数微血管（MV），发现PCa组织中MV数显著高于BPH组（P＜0.01），浸润性PCa组MV数明显高于局限性PCa组（P＜0．05），伴淋巴结转移者MV数显著高于无淋巴结转移者（P＜0．05），未分化PCa组MV数显著高于高分化组及低分化组（P＜0．05），提示肿瘤血管生成与PCa分期、分级密切相关，癌细胞的浸润及转移有赖于肿瘤血管的生成。
To investigate the mechanism of prostate cancer (PCa) cell metastasis, immunohistochemical SP method was used to detect the expression of factor Ⅷ antigen in 36 cases of benign prostatic hyperplasia (BPH) and 34 cases of PCa tissues. Microvessel count (MV) The MV number in the tissue was significantly higher than that in the BPH group (P <0.01). The MV number in the invasive PCa group was significantly higher than that in the PCa group (P <0.05), and the MV number in the patients with lymph node metastasis was significantly higher than that in the BPH group P <0.05). The number of MV in undifferentiated PCa group was significantly higher than that in well differentiated and poorly differentiated groups (P <0.05), suggesting that tumor angiogenesis is closely related to PCa staging and grading, and the invasion and metastasis of cancer cells depend on On the formation of tumor blood vessels.