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白内障的药物治疗仍然面临着严峻的挑战。尽管近 40多种抗白内障药物被广泛的临床使用 ,但证明其有效性的直接证据甚少。醛糖还原酶抑制剂 (ARIs)的副作用严重 ,药物机制“名不符实” ;阿司匹林类药物廉价方便 ,副作用少 ,有望达到预期的效果 ;维生素类抗氧化剂的预防和治疗白内障的作用有限 ,临床资料缺乏可比性 ;糖基化抑制剂 ,谷胱甘肽和药物前体 ,相分离抑制剂和Calpain抑制剂等的研究有较大的进展 ,需要临床研究的进一步验证。可能有效的药物治疗白内障的手段仍将是联合用药的方法。
Medical treatment of cataract still faces serious challenges. Although nearly 40 types of anti-cataract drugs are widely used clinically, there is very little direct evidence of their effectiveness. The side effects of aldose reductase inhibitors (ARIs) are serious, and the drug mechanism is “out of date.” Aspirin drugs are cheap and convenient with few side effects and are expected to achieve the desired effect. Vitamin antioxidants have a limited role in the prevention and treatment of cataracts. Clinical The lack of comparability of data; glycosylation inhibitors, glutathione and prodrugs, phase separation inhibitors and Calpain inhibitors and other research have made great progress, the need for further validation of clinical studies. Potentially effective means of treating cataracts will continue to be a combination therapy.