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对国内四厂家七个批号的阿司匹林肠溶片进行了崩解度,溶出度和生物利用度试验表明:各批号间溶出度差异显著,而各批间崩解度与溶出度;崩解度、溶出度与生物利度间均有较好的相关性。
The disintegration degree, dissolution rate and bioavailability of aspirin enteric-coated tablets of seven batches of four factories in China were tested. The results showed that there was significant difference in the dissolution rates among lots, but the disintegration degree and dissolution rate among batches were different. There was a good correlation between dissolution and bioavailability.