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目的：对照观察（Alzheimer病、Binswanger病（BD）、Parkinson’s病痴呆）。患者血小板及红细胞膜脂质及磷脂各组成分的改变。方法：采用经典方法测定血小板及红细胞膜胆固醇及总磷脂含量，高效液相色谱法测定膜以及血浆磷脂各组成分含量。结果：与对照组比较，BD患者红细胞膜及血小板膜总磷脂、磷脂酰胆碱（PC）、磷脂酸乙醇胺（PE）含量降低，胆固醇、胆固醇与磷脂比值升高，其它两种类型痴呆患者各项测定措标均无明显变化。不同程度大脑白质低密度的BD患者间血小板、红细胞膜PC、PE有显著差异。结论：提示BD患者存在膜磷脂代谢障碍。
Aims: Controlled observation (Alzheimer’s disease, Binswanger’s disease (BD), Parkinson’s disease dementia). Patients with platelet and erythrocyte membrane lipid and phospholipid changes in the composition of each group. Methods: The platelet and erythrocyte membrane cholesterol and total phospholipid content were determined by classical method. The contents of membrane and plasma phospholipid in each group were determined by HPLC. Results: Compared with the control group, the content of total phospholipid, phosphatidylcholine (PC) and phosphatidic acid ethanolamine (PE) in erythrocyte membrane and platelet membrane of BD patients decreased and the ratio of cholesterol, cholesterol and phospholipid increased, while the other two types of patients with dementia Item measurement no significant changes. Different degrees of white matter in patients with low-density white matter BD platelets, erythrocyte membrane PC, PE were significantly different. Conclusion: It suggests that there is membrane phospholipid metabolism disorder in BD patients.