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目的探讨急性脑缺血时血液流变学的变化，为临床治疗急性脑缺血提供实验依据。方法采用ＳＤ大鼠，雌雄兼用，麻醉后结扎颈总动脉，建立急性脑缺血实验模型。动物按实验要求随机分为三组：空白对照组、实验观察组和药物治疗组。脑缺血成功后同时抽血，用锥板粘度计测定血流变学有关指标，并比较各组间差异。结果急性脑缺血大鼠的血液流变学出现明显障碍。表现为低切全血粘度明显增高．血浆粘度增高、且红细胞压积亦有增高表现，但与空白对照组间无显著差异（Ｐ＞０．０５）。红细胞聚集指数增高，血沉加快。血液流变学指标显示红细胞聚集性增强，虽高粘滞综合征表现。结论急性脑缺血可引起血液流变性的紊乱，导致红细胞聚集性增高，提示临床治疗时应注意调整红细胞的聚集性和血液的高粘状况，改善微循环和脑组织灌流。
Objective To investigate the changes of hemorheology in acute cerebral ischemia and provide experimental evidence for clinical treatment of acute cerebral ischemia. Methods Sprague - Dawley rats were used both male and female. The common carotid artery was ligated after anesthesia, and the experimental model of acute cerebral ischemia was established. Animals were randomly divided into three groups according to the experimental requirements: blank control group, experimental observation group and drug treatment group. After successful cerebral ischemia, blood was drawn at the same time. The hemorheology index was measured with cone-plate viscometer. The differences between groups were also compared. Results There was obvious obstacle to hemorheology in acute cerebral ischemia rats. The performance of low cut whole blood viscosity was significantly higher. Plasma viscosity increased, and hematocrit also increased, but there was no significant difference between the control group (P> 0.05). Erythrocyte aggregation index increased, ESR faster. Hemorheological indicators showed enhanced erythrocyte aggregation, although the performance of high-viscosity syndrome. Conclusions Acute cerebral ischemia can cause the disorder of hemorrheology and result in the increase of erythrocyte aggregation. It suggests that the concentration of erythrocytes and hyperviscosity of blood should be adjusted in clinical treatment, and the microcirculation and brain perfusion should be improved.