论文部分内容阅读
目的探讨不稳定型心绞痛(unstable angina pectoris,UAP)患者血清同型半胱氨酸(homocysteine,Hcy)水平与红细胞及血小板参数的关系。方法以2012年8月1日—2015年12月31日在铜陵市立医院心内科住院的60例UAP患者为研究对象,采用循环酶法检测血清Hcy,仪器法检测红细胞参数[红细胞计数、血红蛋白浓度、平均红细胞体积、红细胞体积分布宽度变异系数(coefficient of variation of red blood cell volume distribution width,RDW-CV)]以及血小板参数(血小板计数、血小板体积分布宽度、平均血小板体积、大血小板比率)。根据血清Hcy水平将UAP患者分为UAP伴高同型半胱氨酸血症(hyperhomocystinemia,HHcy)组和UAP正常Hcy组。比较两组患者红细胞及血小板参数水平,并分析UAP患者血清Hcy与红细胞及血小板参数的相关性。结果两组患者红细胞计数、血红蛋白浓度、平均红细胞体积、血小板计数、血小板体积分布宽度、平均血小板体积、大血小板比率差异均无统计学意义(P>0.05),而UAP伴HHcy组RDW-CV(13.81%±1.13%)及其超过参考上限的比例(39.4%)均明显高于UAP正常Hcy组(13.06%±0.97%、14.8%),差异均有统计学意义(P<0.05)。UAP患者血清Hcy与RDW-CV呈正相关(r=0.380,P<0.01),而与其他红细胞参数及血小板参数均无相关性(P>0.05)。结论高水平Hcy影响UAP患者红细胞体积异质性,这可能是HHcy参与UAP发生、发展的作用机制之一。
Objective To investigate the relationship between serum homocysteine (Hcy) levels and erythrocyte and platelet parameters in patients with unstable angina pectoris (UAP). Methods Sixty patients with UAP who were hospitalized in Department of Cardiology, Tongling Municipal Hospital from August 1, 2012 to December 31, 2015 were enrolled in this study. Serum Hcy was detected by circulating enzymatic method. The parameters of erythrocyte [red blood cell count, hemoglobin concentration , Mean erythrocyte volume, coefficient of variation of red blood cell volume distribution width (RDW-CV)] and platelet parameters (platelet count, platelet volume distribution width, mean platelet volume, large platelet ratio). UAP patients were divided into UAP with hyperhomocystinemia (HHcy) group and UAP normal Hcy group according to serum Hcy level. The erythrocyte and platelet parameters were compared between the two groups, and the correlation between serum Hcy and erythrocyte and platelet parameters was analyzed. Results There was no significant difference in erythrocyte count, hemoglobin concentration, mean erythrocyte volume, platelet count, platelet volume distribution width, mean platelet volume and large platelet ratio between the two groups (P> 0.05) (13.81% ± 1.13%) and the proportion exceeding the reference upper limit (39.4%) were significantly higher than those in the HAP normal Hcy group (13.06% ± 0.97% and 14.8%, respectively), with statistical significance (P <0.05). There was a positive correlation between serum Hcy and RDW-CV in patients with UAP (r = 0.380, P <0.01), but not with other erythrocyte parameters and platelet parameters (P> 0.05). Conclusion High level of Hcy affects the volume heterogeneity of erythrocytes in UAP patients, which may be one of the mechanisms of HHcy participating in the occurrence and development of UAP.