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恶性肿瘤是威胁人类健康的主要杀手,而恶性肿瘤的发生是因为细胞的恶变以及逃避了免疫系统的监视[1]。因此如何提高免疫系统对肿瘤的识别及杀伤一直是免疫学研究的热点之一。CD40-D40L作为一对重要的共刺激分子不仅在B细胞、树突状细胞的分化、成熟中有重要作用,而且在肿瘤细胞
Malignancies are a major killer of human health, and malignancies are caused by malignant cells and immune system surveillance [1]. Therefore, how to improve the immune system to recognize and kill tumors has been one of the hot spots in immunology research. As a pair of important costimulatory molecules, CD40-D40L plays an important role not only in the differentiation and maturation of B cells and dendritic cells, but also in tumor cells